Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer’s Disease

A comprehensive intervention (CI) on patients with Alzheimer’s disease was assessed by measuring plasmabrain-derived neurotrophic factor (pBDNF) and ADAS-Cog score (ADAS-Cog(score)) before, immediately after (FU1), and 6 (FU2) and 24 months (FU3) after the CI. Baseline pBDNF was higher in patients w...

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Autores principales: Balietti, Marta, Giuli, Cinzia, Fattoretti, Patrizia, Fabbietti, Paolo, Papa, Roberta, Postacchini, Demetrio, Conti, Fiorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345639/
https://www.ncbi.nlm.nih.gov/pubmed/28222525
http://dx.doi.org/10.3233/JAD-161168
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author Balietti, Marta
Giuli, Cinzia
Fattoretti, Patrizia
Fabbietti, Paolo
Papa, Roberta
Postacchini, Demetrio
Conti, Fiorenzo
author_facet Balietti, Marta
Giuli, Cinzia
Fattoretti, Patrizia
Fabbietti, Paolo
Papa, Roberta
Postacchini, Demetrio
Conti, Fiorenzo
author_sort Balietti, Marta
collection PubMed
description A comprehensive intervention (CI) on patients with Alzheimer’s disease was assessed by measuring plasmabrain-derived neurotrophic factor (pBDNF) and ADAS-Cog score (ADAS-Cog(score)) before, immediately after (FU1), and 6 (FU2) and 24 months (FU3) after the CI. Baseline pBDNF was higher in patients with moderate AD (but not mild AD) than in healthy controls. At FU1, pBDNF and ADAS-Cog(score) decreased significantly. At FU2 and FU3, patients’ cognitive status worsened and pBDNF further increased versus baseline, suggesting that CI interruption may be a stress event that prevents return to homeostasis. CI exerted positive short-term effects, but more information is needed on long-term consequences.
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spelling pubmed-53456392017-03-24 Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer’s Disease Balietti, Marta Giuli, Cinzia Fattoretti, Patrizia Fabbietti, Paolo Papa, Roberta Postacchini, Demetrio Conti, Fiorenzo J Alzheimers Dis Short Communication A comprehensive intervention (CI) on patients with Alzheimer’s disease was assessed by measuring plasmabrain-derived neurotrophic factor (pBDNF) and ADAS-Cog score (ADAS-Cog(score)) before, immediately after (FU1), and 6 (FU2) and 24 months (FU3) after the CI. Baseline pBDNF was higher in patients with moderate AD (but not mild AD) than in healthy controls. At FU1, pBDNF and ADAS-Cog(score) decreased significantly. At FU2 and FU3, patients’ cognitive status worsened and pBDNF further increased versus baseline, suggesting that CI interruption may be a stress event that prevents return to homeostasis. CI exerted positive short-term effects, but more information is needed on long-term consequences. IOS Press 2017-03-04 /pmc/articles/PMC5345639/ /pubmed/28222525 http://dx.doi.org/10.3233/JAD-161168 Text en IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Balietti, Marta
Giuli, Cinzia
Fattoretti, Patrizia
Fabbietti, Paolo
Papa, Roberta
Postacchini, Demetrio
Conti, Fiorenzo
Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer’s Disease
title Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer’s Disease
title_full Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer’s Disease
title_fullStr Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer’s Disease
title_full_unstemmed Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer’s Disease
title_short Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer’s Disease
title_sort effect of a comprehensive intervention on plasma bdnf in patients with alzheimer’s disease
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345639/
https://www.ncbi.nlm.nih.gov/pubmed/28222525
http://dx.doi.org/10.3233/JAD-161168
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