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The Birth of the Modern Era of Parkinson’s Disease Genetics

Genetic understanding in Parkinson’s disease (PD) has followed a path of hard won evolution occasionally punctuated by revolution. While it was suggested early on by both Leroux and Gowers that heredity had a role to play in PD, this was a view that wasn’t widely enough held to even be unpopular. Th...

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Detalles Bibliográficos
Autores principales: Singleton, Andrew B., Hardy, John A., Gasser, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345643/
https://www.ncbi.nlm.nih.gov/pubmed/28282818
http://dx.doi.org/10.3233/JPD-179009
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author Singleton, Andrew B.
Hardy, John A.
Gasser, Thomas
author_facet Singleton, Andrew B.
Hardy, John A.
Gasser, Thomas
author_sort Singleton, Andrew B.
collection PubMed
description Genetic understanding in Parkinson’s disease (PD) has followed a path of hard won evolution occasionally punctuated by revolution. While it was suggested early on by both Leroux and Gowers that heredity had a role to play in PD, this was a view that wasn’t widely enough held to even be unpopular. The dogma was that the disease was one of environmental provenance and while the evidence for this is still rather scarce, this view pervades in the minds of patients, clinicians, and scientists. Conversely the evidence linking genetics to PD is both overwhelming and growing. Here we describe the growth of genetics in PD from backwater to driving force, and the structure and shape of its future.
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spelling pubmed-53456432017-03-24 The Birth of the Modern Era of Parkinson’s Disease Genetics Singleton, Andrew B. Hardy, John A. Gasser, Thomas J Parkinsons Dis Review Genetic understanding in Parkinson’s disease (PD) has followed a path of hard won evolution occasionally punctuated by revolution. While it was suggested early on by both Leroux and Gowers that heredity had a role to play in PD, this was a view that wasn’t widely enough held to even be unpopular. The dogma was that the disease was one of environmental provenance and while the evidence for this is still rather scarce, this view pervades in the minds of patients, clinicians, and scientists. Conversely the evidence linking genetics to PD is both overwhelming and growing. Here we describe the growth of genetics in PD from backwater to driving force, and the structure and shape of its future. IOS Press 2017-03-06 /pmc/articles/PMC5345643/ /pubmed/28282818 http://dx.doi.org/10.3233/JPD-179009 Text en IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Singleton, Andrew B.
Hardy, John A.
Gasser, Thomas
The Birth of the Modern Era of Parkinson’s Disease Genetics
title The Birth of the Modern Era of Parkinson’s Disease Genetics
title_full The Birth of the Modern Era of Parkinson’s Disease Genetics
title_fullStr The Birth of the Modern Era of Parkinson’s Disease Genetics
title_full_unstemmed The Birth of the Modern Era of Parkinson’s Disease Genetics
title_short The Birth of the Modern Era of Parkinson’s Disease Genetics
title_sort birth of the modern era of parkinson’s disease genetics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345643/
https://www.ncbi.nlm.nih.gov/pubmed/28282818
http://dx.doi.org/10.3233/JPD-179009
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