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Evaluation of a DNA Aβ(42) Vaccine in Aged NZW Rabbits: Antibody Kinetics and Immune Profile after Intradermal Immunization with Full-Length DNA Aβ(42) Trimer

A pathological hallmark of Alzheimer’s disease (AD) are amyloid plaques in the brain consisting of aggregated amyloid-β 42 peptide (Aβ(42)) derived from cellular amyloid-β protein precursor (AβPP). Based on successful experiments in mouse AD models, active immunization with Aβ(42) peptide and passiv...

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Detalles Bibliográficos
Autores principales:	Lambracht-Washington, Doris, Fu, Min, Wight-Carter, Mary, Riegel, Matthew, Rosenberg, Roger N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345648/ https://www.ncbi.nlm.nih.gov/pubmed/28222511 http://dx.doi.org/10.3233/JAD-160947

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