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The Synucleinopathies: Twenty Years On
In 2017, it is two hundred years since James Parkinson provided the first complete clinical description of the disease named after him, fifty years since the introduction of high-dose D,L-DOPA treatment and twenty years since α-synuclein aggregation came to the fore. In 1998, multiple system atrophy...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345650/ https://www.ncbi.nlm.nih.gov/pubmed/28282814 http://dx.doi.org/10.3233/JPD-179005 |
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author | Goedert, Michel Jakes, Ross Spillantini, Maria Grazia |
author_facet | Goedert, Michel Jakes, Ross Spillantini, Maria Grazia |
author_sort | Goedert, Michel |
collection | PubMed |
description | In 2017, it is two hundred years since James Parkinson provided the first complete clinical description of the disease named after him, fifty years since the introduction of high-dose D,L-DOPA treatment and twenty years since α-synuclein aggregation came to the fore. In 1998, multiple system atrophy joined Parkinson’s disease and dementia with Lewy bodies as the third major synucleinopathy. Here we review our work, which led to the identification of α-synuclein in Lewy bodies, Lewy neurites and Papp-Lantos bodies, as well as what has happened since. Some of the experiments described were carried out in collaboration with ML Schmidt, VMY Lee and JQ Trojanowski. |
format | Online Article Text |
id | pubmed-5345650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-53456502017-03-24 The Synucleinopathies: Twenty Years On Goedert, Michel Jakes, Ross Spillantini, Maria Grazia J Parkinsons Dis Review In 2017, it is two hundred years since James Parkinson provided the first complete clinical description of the disease named after him, fifty years since the introduction of high-dose D,L-DOPA treatment and twenty years since α-synuclein aggregation came to the fore. In 1998, multiple system atrophy joined Parkinson’s disease and dementia with Lewy bodies as the third major synucleinopathy. Here we review our work, which led to the identification of α-synuclein in Lewy bodies, Lewy neurites and Papp-Lantos bodies, as well as what has happened since. Some of the experiments described were carried out in collaboration with ML Schmidt, VMY Lee and JQ Trojanowski. IOS Press 2017-03-06 /pmc/articles/PMC5345650/ /pubmed/28282814 http://dx.doi.org/10.3233/JPD-179005 Text en IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Goedert, Michel Jakes, Ross Spillantini, Maria Grazia The Synucleinopathies: Twenty Years On |
title | The Synucleinopathies: Twenty Years On |
title_full | The Synucleinopathies: Twenty Years On |
title_fullStr | The Synucleinopathies: Twenty Years On |
title_full_unstemmed | The Synucleinopathies: Twenty Years On |
title_short | The Synucleinopathies: Twenty Years On |
title_sort | synucleinopathies: twenty years on |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345650/ https://www.ncbi.nlm.nih.gov/pubmed/28282814 http://dx.doi.org/10.3233/JPD-179005 |
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