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Lack of Association of CD55 Receptor Genetic Variants and Severe Malaria in Ghanaian Children
In a recent report, the cellular receptor CD55 was identified as a molecule essential for the invasion of human erythrocytes by Plasmodium falciparum, the causal agent of the most severe form of malaria. As this invasion process represents a critical step during infection with the parasite, it was h...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Genetics Society of America
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345716/ https://www.ncbi.nlm.nih.gov/pubmed/28104671 http://dx.doi.org/10.1534/g3.116.036475 |
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author | Schuldt, Kathrin Ehmen, Christa Sievertsen, Juergen Evans, Jennifer May, Juergen Ansong, Daniel Muntau, Birgit Ruge, Gerd Timmann, Christian Agbenyega, Tsiri Horstmann, Rolf D. Thye, Thorsten |
author_facet | Schuldt, Kathrin Ehmen, Christa Sievertsen, Juergen Evans, Jennifer May, Juergen Ansong, Daniel Muntau, Birgit Ruge, Gerd Timmann, Christian Agbenyega, Tsiri Horstmann, Rolf D. Thye, Thorsten |
author_sort | Schuldt, Kathrin |
collection | PubMed |
description | In a recent report, the cellular receptor CD55 was identified as a molecule essential for the invasion of human erythrocytes by Plasmodium falciparum, the causal agent of the most severe form of malaria. As this invasion process represents a critical step during infection with the parasite, it was hypothesized that genetic variants in the gene could affect severe malaria (SM) susceptibility. We performed high-resolution variant discovery of rare and common genetic variants in the human CD55 gene. Association testing of these variants in over 1700 SM cases and unaffected control individuals from the malaria-endemic Ashanti Region in Ghana, West Africa, were performed on the basis of single variants, combined rare variant analyses, and reconstructed haplotypes. A total of 26 genetic variants were detected in coding and regulatory regions of CD55. Five variants were previously unknown. None of the single variants, rare variants, or haplotypes showed evidence for association with SM or P. falciparum density. Here, we present the first comprehensive analysis of variation in the CD55 gene in the context of SM and show that genetic variants present in a Ghanaian study group appear not to influence susceptibility to the disease. |
format | Online Article Text |
id | pubmed-5345716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Genetics Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-53457162017-03-21 Lack of Association of CD55 Receptor Genetic Variants and Severe Malaria in Ghanaian Children Schuldt, Kathrin Ehmen, Christa Sievertsen, Juergen Evans, Jennifer May, Juergen Ansong, Daniel Muntau, Birgit Ruge, Gerd Timmann, Christian Agbenyega, Tsiri Horstmann, Rolf D. Thye, Thorsten G3 (Bethesda) Investigations In a recent report, the cellular receptor CD55 was identified as a molecule essential for the invasion of human erythrocytes by Plasmodium falciparum, the causal agent of the most severe form of malaria. As this invasion process represents a critical step during infection with the parasite, it was hypothesized that genetic variants in the gene could affect severe malaria (SM) susceptibility. We performed high-resolution variant discovery of rare and common genetic variants in the human CD55 gene. Association testing of these variants in over 1700 SM cases and unaffected control individuals from the malaria-endemic Ashanti Region in Ghana, West Africa, were performed on the basis of single variants, combined rare variant analyses, and reconstructed haplotypes. A total of 26 genetic variants were detected in coding and regulatory regions of CD55. Five variants were previously unknown. None of the single variants, rare variants, or haplotypes showed evidence for association with SM or P. falciparum density. Here, we present the first comprehensive analysis of variation in the CD55 gene in the context of SM and show that genetic variants present in a Ghanaian study group appear not to influence susceptibility to the disease. Genetics Society of America 2017-01-18 /pmc/articles/PMC5345716/ /pubmed/28104671 http://dx.doi.org/10.1534/g3.116.036475 Text en Copyright © 2017 Schuldt et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Investigations Schuldt, Kathrin Ehmen, Christa Sievertsen, Juergen Evans, Jennifer May, Juergen Ansong, Daniel Muntau, Birgit Ruge, Gerd Timmann, Christian Agbenyega, Tsiri Horstmann, Rolf D. Thye, Thorsten Lack of Association of CD55 Receptor Genetic Variants and Severe Malaria in Ghanaian Children |
title | Lack of Association of CD55 Receptor Genetic Variants and Severe Malaria in Ghanaian Children |
title_full | Lack of Association of CD55 Receptor Genetic Variants and Severe Malaria in Ghanaian Children |
title_fullStr | Lack of Association of CD55 Receptor Genetic Variants and Severe Malaria in Ghanaian Children |
title_full_unstemmed | Lack of Association of CD55 Receptor Genetic Variants and Severe Malaria in Ghanaian Children |
title_short | Lack of Association of CD55 Receptor Genetic Variants and Severe Malaria in Ghanaian Children |
title_sort | lack of association of cd55 receptor genetic variants and severe malaria in ghanaian children |
topic | Investigations |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345716/ https://www.ncbi.nlm.nih.gov/pubmed/28104671 http://dx.doi.org/10.1534/g3.116.036475 |
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