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Histopathology and enhanced detection of tumor invasion of peritoneal membranes

Tumor invasion of the peritoneal membrane may have an adverse prognostic significance, but its histopathologic features can be diagnostically difficult to recognize. We observed that local peritoneal injury associated with tumor invasion is characterized by activation and proliferation of serosal st...

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Autores principales: Chen, Jey-Hsin, Borges, Melissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345882/
https://www.ncbi.nlm.nih.gov/pubmed/28282462
http://dx.doi.org/10.1371/journal.pone.0173833
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author Chen, Jey-Hsin
Borges, Melissa
author_facet Chen, Jey-Hsin
Borges, Melissa
author_sort Chen, Jey-Hsin
collection PubMed
description Tumor invasion of the peritoneal membrane may have an adverse prognostic significance, but its histopathologic features can be diagnostically difficult to recognize. We observed that local peritoneal injury associated with tumor invasion is characterized by activation and proliferation of serosal stromal cells that express cytokeratin, a characteristic property of injured serosal membranes that may have diagnostic utility. To explore this, we examined 120 primary tumors of the gastrointestinal tract and pancreaticobiliary system using cytokeratin and elastic stains to assess for tumor invasion of peritoneal membranes. Peritoneal invasion by tumor was associated with retraction, splaying, and destruction of the elastic lamina and proliferation of keratin-expressing stromal cells of serosal membranes. All 82 peritoneal invasive tumors were characterized by neoplastic cells that invaded the elastic lamina and the serosal connective tissue with neoplastic cells that abutted or were surrounded by keratin-positive stromal cells, whereas all 38 tumors limited to the subserosa showed none of these features. The diagnosis of tumor invasion of peritoneal membranes is enhanced by the combined use of cytokeratin and elastic stains, which in turn would enable better histopathologic correlation with patient treatment and outcome.
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spelling pubmed-53458822017-03-30 Histopathology and enhanced detection of tumor invasion of peritoneal membranes Chen, Jey-Hsin Borges, Melissa PLoS One Research Article Tumor invasion of the peritoneal membrane may have an adverse prognostic significance, but its histopathologic features can be diagnostically difficult to recognize. We observed that local peritoneal injury associated with tumor invasion is characterized by activation and proliferation of serosal stromal cells that express cytokeratin, a characteristic property of injured serosal membranes that may have diagnostic utility. To explore this, we examined 120 primary tumors of the gastrointestinal tract and pancreaticobiliary system using cytokeratin and elastic stains to assess for tumor invasion of peritoneal membranes. Peritoneal invasion by tumor was associated with retraction, splaying, and destruction of the elastic lamina and proliferation of keratin-expressing stromal cells of serosal membranes. All 82 peritoneal invasive tumors were characterized by neoplastic cells that invaded the elastic lamina and the serosal connective tissue with neoplastic cells that abutted or were surrounded by keratin-positive stromal cells, whereas all 38 tumors limited to the subserosa showed none of these features. The diagnosis of tumor invasion of peritoneal membranes is enhanced by the combined use of cytokeratin and elastic stains, which in turn would enable better histopathologic correlation with patient treatment and outcome. Public Library of Science 2017-03-10 /pmc/articles/PMC5345882/ /pubmed/28282462 http://dx.doi.org/10.1371/journal.pone.0173833 Text en © 2017 Chen, Borges http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Chen, Jey-Hsin
Borges, Melissa
Histopathology and enhanced detection of tumor invasion of peritoneal membranes
title Histopathology and enhanced detection of tumor invasion of peritoneal membranes
title_full Histopathology and enhanced detection of tumor invasion of peritoneal membranes
title_fullStr Histopathology and enhanced detection of tumor invasion of peritoneal membranes
title_full_unstemmed Histopathology and enhanced detection of tumor invasion of peritoneal membranes
title_short Histopathology and enhanced detection of tumor invasion of peritoneal membranes
title_sort histopathology and enhanced detection of tumor invasion of peritoneal membranes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345882/
https://www.ncbi.nlm.nih.gov/pubmed/28282462
http://dx.doi.org/10.1371/journal.pone.0173833
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