Romidepsin-induced HIV-1 viremia during effective antiretroviral therapy contains identical viral sequences with few deleterious mutations

OBJECTIVE: To investigate the origin of the HIV-1 viremia induced by the latency-reversing agent romidepsin. DESIGN: Six individuals on suppressive antiretroviral therapy received romidepsin administered intravenously once weekly for 3 consecutive weeks. CD4(+) T cells were obtained at baseline, fol...

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Detalles Bibliográficos
Autores principales: Winckelmann, Anni, Barton, Kirston, Hiener, Bonnie, Schlub, Timothy E., Shao, Wei, Rasmussen, Thomas A., Østergaard, Lars, Søgaard, Ole S., Tolstrup, Martin, Palmer, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Clinical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345886/
https://www.ncbi.nlm.nih.gov/pubmed/28272134
http://dx.doi.org/10.1097/QAD.0000000000001400

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