Long-acting combination anti-HIV drug suspension enhances and sustains higher drug levels in lymph node cells than in blood cells and plasma

OBJECTIVE: The aim of the present study was to determine whether a combination of anti-HIV drugs – tenofovir (TFV), lopinavir (LPV) and ritonavir (RTV) – in a lipid-stabilized nanosuspension (called TLC-ART101) could enhance and sustain intracellular drug levels and exposures in lymph node and blood...

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Detalles Bibliográficos
Autores principales: Kraft, John C., McConnachie, Lisa A., Koehn, Josefin, Kinman, Loren, Collins, Carol, Shen, Danny D., Collier, Ann C., Ho, Rodney J.Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Basic Science: Concise Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345888/
https://www.ncbi.nlm.nih.gov/pubmed/28099191
http://dx.doi.org/10.1097/QAD.0000000000001405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345888/
https://www.ncbi.nlm.nih.gov/pubmed/28099191
http://dx.doi.org/10.1097/QAD.0000000000001405

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