TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

Many lines of evidence have indicated that both genetic and non-genetic determinants can contribute to intra-tumor heterogeneity and influence cancer outcomes. Among the best described sub-population of cancer cells generated by non-genetic mechanisms are cells characterized by a CD44+/CD24− cell su...

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Detalles Bibliográficos
Autores principales: Pal, Debjani, Pertot, Anja, Shirole, Nitin H, Yao, Zhan, Anaparthy, Naishitha, Garvin, Tyler, Cox, Hilary, Chang, Kenneth, Rollins, Fred, Kendall, Jude, Edwards, Leyla, Singh, Vijay A, Stone, Gary C, Schatz, Michael C, Hicks, James, Hannon, Gregory J, Sordella, Raffaella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345931/
https://www.ncbi.nlm.nih.gov/pubmed/28092266
http://dx.doi.org/10.7554/eLife.21615

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