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Altered functional brain connectivity in patients with visually induced dizziness

BACKGROUND: Vestibular patients occasionally report aggravation or triggering of their symptoms by visual stimuli, which is called visually induced dizziness (VID). These patients therefore experience dizziness, discomfort, disorientation and postural unsteadiness. The underlying pathophysiology of...

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Autores principales: Van Ombergen, Angelique, Heine, Lizette, Jillings, Steven, Roberts, R. Edward, Jeurissen, Ben, Van Rompaey, Vincent, Mucci, Viviana, Vanhecke, Stefanie, Sijbers, Jan, Vanhevel, Floris, Sunaert, Stefan, Bahri, Mohamed Ali, Parizel, Paul M., Van de Heyning, Paul H., Laureys, Steven, Wuyts, Floris L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345975/
https://www.ncbi.nlm.nih.gov/pubmed/28331800
http://dx.doi.org/10.1016/j.nicl.2017.02.020
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author Van Ombergen, Angelique
Heine, Lizette
Jillings, Steven
Roberts, R. Edward
Jeurissen, Ben
Van Rompaey, Vincent
Mucci, Viviana
Vanhecke, Stefanie
Sijbers, Jan
Vanhevel, Floris
Sunaert, Stefan
Bahri, Mohamed Ali
Parizel, Paul M.
Van de Heyning, Paul H.
Laureys, Steven
Wuyts, Floris L.
author_facet Van Ombergen, Angelique
Heine, Lizette
Jillings, Steven
Roberts, R. Edward
Jeurissen, Ben
Van Rompaey, Vincent
Mucci, Viviana
Vanhecke, Stefanie
Sijbers, Jan
Vanhevel, Floris
Sunaert, Stefan
Bahri, Mohamed Ali
Parizel, Paul M.
Van de Heyning, Paul H.
Laureys, Steven
Wuyts, Floris L.
author_sort Van Ombergen, Angelique
collection PubMed
description BACKGROUND: Vestibular patients occasionally report aggravation or triggering of their symptoms by visual stimuli, which is called visually induced dizziness (VID). These patients therefore experience dizziness, discomfort, disorientation and postural unsteadiness. The underlying pathophysiology of VID is still poorly understood. OBJECTIVE: The aim of the current explorative study was to gain a first insight in the underlying neural aspects of VID. METHODS: We included 10 VID patients and 10 healthy matched controls, all of which underwent a resting state fMRI scan session. Changes in functional connectivity were explored by means of the intrinsic connectivity contrast (ICC). Seed-based analysis was subsequently performed in visual and vestibular seeds. RESULTS: We found a decreased functional connectivity in the right central operculum (superior temporal gyrus), as well as increased functional connectivity in the occipital pole in VID patients as compared to controls in a hypothesis-free analysis. A weaker functional connectivity between the thalamus and most of the right putamen was measured in VID patients in comparison to controls in a seed-based analysis. Furthermore, also by means of a seed-based analysis, a decreased functional connectivity between the visual associative area and the left parahippocampal gyrus was found in VID patients. Additionally, we found increased functional connectivity between thalamus and occipital and cerebellar areas in the VID patients, as well as between the associative visual cortex and both middle frontal gyrus and precuneus. CONCLUSIONS: We found alterations in the visual and vestibular cortical network in VID patients that could underlie the typical VID symptoms such as a worsening of their vestibular symptoms when being exposed to challenging visual stimuli. These preliminary findings provide the first insights into the underlying functional brain connectivity in VID patients. Future studies should extend these findings by employing larger sample sizes, by investigating specific task-based paradigms in these patients and by exploring the implications for treatment.
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spelling pubmed-53459752017-03-22 Altered functional brain connectivity in patients with visually induced dizziness Van Ombergen, Angelique Heine, Lizette Jillings, Steven Roberts, R. Edward Jeurissen, Ben Van Rompaey, Vincent Mucci, Viviana Vanhecke, Stefanie Sijbers, Jan Vanhevel, Floris Sunaert, Stefan Bahri, Mohamed Ali Parizel, Paul M. Van de Heyning, Paul H. Laureys, Steven Wuyts, Floris L. Neuroimage Clin Regular Article BACKGROUND: Vestibular patients occasionally report aggravation or triggering of their symptoms by visual stimuli, which is called visually induced dizziness (VID). These patients therefore experience dizziness, discomfort, disorientation and postural unsteadiness. The underlying pathophysiology of VID is still poorly understood. OBJECTIVE: The aim of the current explorative study was to gain a first insight in the underlying neural aspects of VID. METHODS: We included 10 VID patients and 10 healthy matched controls, all of which underwent a resting state fMRI scan session. Changes in functional connectivity were explored by means of the intrinsic connectivity contrast (ICC). Seed-based analysis was subsequently performed in visual and vestibular seeds. RESULTS: We found a decreased functional connectivity in the right central operculum (superior temporal gyrus), as well as increased functional connectivity in the occipital pole in VID patients as compared to controls in a hypothesis-free analysis. A weaker functional connectivity between the thalamus and most of the right putamen was measured in VID patients in comparison to controls in a seed-based analysis. Furthermore, also by means of a seed-based analysis, a decreased functional connectivity between the visual associative area and the left parahippocampal gyrus was found in VID patients. Additionally, we found increased functional connectivity between thalamus and occipital and cerebellar areas in the VID patients, as well as between the associative visual cortex and both middle frontal gyrus and precuneus. CONCLUSIONS: We found alterations in the visual and vestibular cortical network in VID patients that could underlie the typical VID symptoms such as a worsening of their vestibular symptoms when being exposed to challenging visual stimuli. These preliminary findings provide the first insights into the underlying functional brain connectivity in VID patients. Future studies should extend these findings by employing larger sample sizes, by investigating specific task-based paradigms in these patients and by exploring the implications for treatment. Elsevier 2017-02-28 /pmc/articles/PMC5345975/ /pubmed/28331800 http://dx.doi.org/10.1016/j.nicl.2017.02.020 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Van Ombergen, Angelique
Heine, Lizette
Jillings, Steven
Roberts, R. Edward
Jeurissen, Ben
Van Rompaey, Vincent
Mucci, Viviana
Vanhecke, Stefanie
Sijbers, Jan
Vanhevel, Floris
Sunaert, Stefan
Bahri, Mohamed Ali
Parizel, Paul M.
Van de Heyning, Paul H.
Laureys, Steven
Wuyts, Floris L.
Altered functional brain connectivity in patients with visually induced dizziness
title Altered functional brain connectivity in patients with visually induced dizziness
title_full Altered functional brain connectivity in patients with visually induced dizziness
title_fullStr Altered functional brain connectivity in patients with visually induced dizziness
title_full_unstemmed Altered functional brain connectivity in patients with visually induced dizziness
title_short Altered functional brain connectivity in patients with visually induced dizziness
title_sort altered functional brain connectivity in patients with visually induced dizziness
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345975/
https://www.ncbi.nlm.nih.gov/pubmed/28331800
http://dx.doi.org/10.1016/j.nicl.2017.02.020
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