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The risk of renal disease is increased in lambda myeloma with bone marrow amyloid deposits

BACKGROUND: Light chain amyloidosis (AL) is a rare deposition disease and is present in 10–15% of patients with myeloma (MM). In contrast to symptomatic AL in MM, presence of bone marrow (BM) amyloid deposits (AD) in MM is not connected to kidney damage. Renal AD but not BM-AD occur mostly in MM wit...

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Autores principales: Kozlowski, Piotr, Montgomery, Scott, Befekadu, Rahel, Hahn-Strömberg, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345990/
https://www.ncbi.nlm.nih.gov/pubmed/28293126
http://dx.doi.org/10.2147/JBM.S129516
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author Kozlowski, Piotr
Montgomery, Scott
Befekadu, Rahel
Hahn-Strömberg, Victoria
author_facet Kozlowski, Piotr
Montgomery, Scott
Befekadu, Rahel
Hahn-Strömberg, Victoria
author_sort Kozlowski, Piotr
collection PubMed
description BACKGROUND: Light chain amyloidosis (AL) is a rare deposition disease and is present in 10–15% of patients with myeloma (MM). In contrast to symptomatic AL in MM, presence of bone marrow (BM) amyloid deposits (AD) in MM is not connected to kidney damage. Renal AD but not BM-AD occur mostly in MM with lambda paraprotein (lambda MM). METHODS: We investigated amyloid presence in BM clots taken at diagnosis in 84 patients with symptomatic MM and compared disease characteristics in MM with kappa paraprotein (kappa MM)/lambda MM with and without BM-AD. RESULTS: Lambda MM with BM-AD was compared with kappa MM without BM-AD, kappa MM with BM-AD, and lambda MM without BM-AD: lambda MM with BM-AD patients had a significantly higher mean creatinine level (4.23 mg/dL vs 1.69, 1.14, and 1.28 mg/dL, respectively) and a higher proportion presented with severe kidney failure (6/11 [55%] vs 6/32 [19%], 1/22 [5%], and 3/19 [16%], respectively). Proteinuria was more common in lambda MM with BM-AD patients compared with kappa MM without BM-AD patients (8/11 [73%] vs 5/32 [16%], respectively). CONCLUSION: Kidney damage was more common in lambda MM with BM-AD indicating presence of renal AD.
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spelling pubmed-53459902017-03-14 The risk of renal disease is increased in lambda myeloma with bone marrow amyloid deposits Kozlowski, Piotr Montgomery, Scott Befekadu, Rahel Hahn-Strömberg, Victoria J Blood Med Original Research BACKGROUND: Light chain amyloidosis (AL) is a rare deposition disease and is present in 10–15% of patients with myeloma (MM). In contrast to symptomatic AL in MM, presence of bone marrow (BM) amyloid deposits (AD) in MM is not connected to kidney damage. Renal AD but not BM-AD occur mostly in MM with lambda paraprotein (lambda MM). METHODS: We investigated amyloid presence in BM clots taken at diagnosis in 84 patients with symptomatic MM and compared disease characteristics in MM with kappa paraprotein (kappa MM)/lambda MM with and without BM-AD. RESULTS: Lambda MM with BM-AD was compared with kappa MM without BM-AD, kappa MM with BM-AD, and lambda MM without BM-AD: lambda MM with BM-AD patients had a significantly higher mean creatinine level (4.23 mg/dL vs 1.69, 1.14, and 1.28 mg/dL, respectively) and a higher proportion presented with severe kidney failure (6/11 [55%] vs 6/32 [19%], 1/22 [5%], and 3/19 [16%], respectively). Proteinuria was more common in lambda MM with BM-AD patients compared with kappa MM without BM-AD patients (8/11 [73%] vs 5/32 [16%], respectively). CONCLUSION: Kidney damage was more common in lambda MM with BM-AD indicating presence of renal AD. Dove Medical Press 2017-03-06 /pmc/articles/PMC5345990/ /pubmed/28293126 http://dx.doi.org/10.2147/JBM.S129516 Text en © 2017 Kozlowski et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Kozlowski, Piotr
Montgomery, Scott
Befekadu, Rahel
Hahn-Strömberg, Victoria
The risk of renal disease is increased in lambda myeloma with bone marrow amyloid deposits
title The risk of renal disease is increased in lambda myeloma with bone marrow amyloid deposits
title_full The risk of renal disease is increased in lambda myeloma with bone marrow amyloid deposits
title_fullStr The risk of renal disease is increased in lambda myeloma with bone marrow amyloid deposits
title_full_unstemmed The risk of renal disease is increased in lambda myeloma with bone marrow amyloid deposits
title_short The risk of renal disease is increased in lambda myeloma with bone marrow amyloid deposits
title_sort risk of renal disease is increased in lambda myeloma with bone marrow amyloid deposits
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345990/
https://www.ncbi.nlm.nih.gov/pubmed/28293126
http://dx.doi.org/10.2147/JBM.S129516
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