The role of Notch signalling in ovarian angiogenesis

In adults, the ovary is characterized with extensive angiogenesis and regular intervals of rapid growth. Ovarian function is dependent on the network of angiogenic vessels which enable the follicle and/or corpus luteum to receive oxygen, nutrients and hormonal support. Abnormal angiogenesis is invol...

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Autores principales: Xie, Qi, Cheng, Zuowang, Chen, Xiaocui, Lobe, Corrinne G., Liu, Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346233/
https://www.ncbi.nlm.nih.gov/pubmed/28284219
http://dx.doi.org/10.1186/s13048-017-0308-5
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author Xie, Qi
Cheng, Zuowang
Chen, Xiaocui
Lobe, Corrinne G.
Liu, Ju
author_facet Xie, Qi
Cheng, Zuowang
Chen, Xiaocui
Lobe, Corrinne G.
Liu, Ju
author_sort Xie, Qi
collection PubMed
description In adults, the ovary is characterized with extensive angiogenesis and regular intervals of rapid growth. Ovarian function is dependent on the network of angiogenic vessels which enable the follicle and/or corpus luteum to receive oxygen, nutrients and hormonal support. Abnormal angiogenesis is involved in the induction and development of pathological ovary, such as polycystic ovary syndrome and ovarian cancer. Notch signalling pathway is one of the primary regulators of angiogenesis and a therapeutic target for ovarian diseases. Here, we will review literatures on the expression pattern of Notch pathway components in the ovary and on the role of Notch signalling pathway on ovarian angiogenesis.
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spelling pubmed-53462332017-03-14 The role of Notch signalling in ovarian angiogenesis Xie, Qi Cheng, Zuowang Chen, Xiaocui Lobe, Corrinne G. Liu, Ju J Ovarian Res Review In adults, the ovary is characterized with extensive angiogenesis and regular intervals of rapid growth. Ovarian function is dependent on the network of angiogenic vessels which enable the follicle and/or corpus luteum to receive oxygen, nutrients and hormonal support. Abnormal angiogenesis is involved in the induction and development of pathological ovary, such as polycystic ovary syndrome and ovarian cancer. Notch signalling pathway is one of the primary regulators of angiogenesis and a therapeutic target for ovarian diseases. Here, we will review literatures on the expression pattern of Notch pathway components in the ovary and on the role of Notch signalling pathway on ovarian angiogenesis. BioMed Central 2017-03-11 /pmc/articles/PMC5346233/ /pubmed/28284219 http://dx.doi.org/10.1186/s13048-017-0308-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Xie, Qi
Cheng, Zuowang
Chen, Xiaocui
Lobe, Corrinne G.
Liu, Ju
The role of Notch signalling in ovarian angiogenesis
title The role of Notch signalling in ovarian angiogenesis
title_full The role of Notch signalling in ovarian angiogenesis
title_fullStr The role of Notch signalling in ovarian angiogenesis
title_full_unstemmed The role of Notch signalling in ovarian angiogenesis
title_short The role of Notch signalling in ovarian angiogenesis
title_sort role of notch signalling in ovarian angiogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346233/
https://www.ncbi.nlm.nih.gov/pubmed/28284219
http://dx.doi.org/10.1186/s13048-017-0308-5
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