Physiological fidelity or model parsimony? The relative performance of reverse-toxicokinetic modeling approaches

BACKGROUND: Physiologically-based toxicokinetic (PBTK) models are often developed to facilitate in vitro to in vivo extrapolation (IVIVE) using a top-down, compartmental approach, favoring architectural simplicity over physiological fidelity despite the lack of general guidelines relating model desi...

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Detalles Bibliográficos
Autores principales: Rowland, Michael A., Perkins, Edward J., Mayo, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346271/
https://www.ncbi.nlm.nih.gov/pubmed/28284215
http://dx.doi.org/10.1186/s12918-017-0407-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346271/
https://www.ncbi.nlm.nih.gov/pubmed/28284215
http://dx.doi.org/10.1186/s12918-017-0407-3

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