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Physiological fidelity or model parsimony? The relative performance of reverse-toxicokinetic modeling approaches
BACKGROUND: Physiologically-based toxicokinetic (PBTK) models are often developed to facilitate in vitro to in vivo extrapolation (IVIVE) using a top-down, compartmental approach, favoring architectural simplicity over physiological fidelity despite the lack of general guidelines relating model desi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346271/ https://www.ncbi.nlm.nih.gov/pubmed/28284215 http://dx.doi.org/10.1186/s12918-017-0407-3 |