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Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications

Tumor consists of heterogeneous cancer cells including cancer stem cells (CSCs) that can terminally differentiate into tumor bulk. Normal stem cells in normal organs regulate self-renewal within a stem cell niche. Likewise, accumulating evidence has also suggested that CSCs are maintained extrinsica...

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Detalles Bibliográficos
Autores principales: Lau, Eunice Yuen-Ting, Ho, Nicole Pui-Yu, Lee, Terence Kin-Wah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346399/
https://www.ncbi.nlm.nih.gov/pubmed/28337221
http://dx.doi.org/10.1155/2017/3714190
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author Lau, Eunice Yuen-Ting
Ho, Nicole Pui-Yu
Lee, Terence Kin-Wah
author_facet Lau, Eunice Yuen-Ting
Ho, Nicole Pui-Yu
Lee, Terence Kin-Wah
author_sort Lau, Eunice Yuen-Ting
collection PubMed
description Tumor consists of heterogeneous cancer cells including cancer stem cells (CSCs) that can terminally differentiate into tumor bulk. Normal stem cells in normal organs regulate self-renewal within a stem cell niche. Likewise, accumulating evidence has also suggested that CSCs are maintained extrinsically within the tumor microenvironment, which includes both cellular and physical factors. Here, we review the significance of stromal cells, immune cells, extracellular matrix, tumor stiffness, and hypoxia in regulation of CSC plasticity and therapeutic resistance. With a better understanding of how CSC interacts with its niche, we are able to identify potential therapeutic targets for the development of more effective treatments against cancer.
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spelling pubmed-53463992017-03-23 Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications Lau, Eunice Yuen-Ting Ho, Nicole Pui-Yu Lee, Terence Kin-Wah Stem Cells Int Review Article Tumor consists of heterogeneous cancer cells including cancer stem cells (CSCs) that can terminally differentiate into tumor bulk. Normal stem cells in normal organs regulate self-renewal within a stem cell niche. Likewise, accumulating evidence has also suggested that CSCs are maintained extrinsically within the tumor microenvironment, which includes both cellular and physical factors. Here, we review the significance of stromal cells, immune cells, extracellular matrix, tumor stiffness, and hypoxia in regulation of CSC plasticity and therapeutic resistance. With a better understanding of how CSC interacts with its niche, we are able to identify potential therapeutic targets for the development of more effective treatments against cancer. Hindawi Publishing Corporation 2017 2017-02-26 /pmc/articles/PMC5346399/ /pubmed/28337221 http://dx.doi.org/10.1155/2017/3714190 Text en Copyright © 2017 Eunice Yuen-Ting Lau et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lau, Eunice Yuen-Ting
Ho, Nicole Pui-Yu
Lee, Terence Kin-Wah
Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications
title Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications
title_full Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications
title_fullStr Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications
title_full_unstemmed Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications
title_short Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications
title_sort cancer stem cells and their microenvironment: biology and therapeutic implications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346399/
https://www.ncbi.nlm.nih.gov/pubmed/28337221
http://dx.doi.org/10.1155/2017/3714190
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