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Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications
Tumor consists of heterogeneous cancer cells including cancer stem cells (CSCs) that can terminally differentiate into tumor bulk. Normal stem cells in normal organs regulate self-renewal within a stem cell niche. Likewise, accumulating evidence has also suggested that CSCs are maintained extrinsica...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346399/ https://www.ncbi.nlm.nih.gov/pubmed/28337221 http://dx.doi.org/10.1155/2017/3714190 |
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author | Lau, Eunice Yuen-Ting Ho, Nicole Pui-Yu Lee, Terence Kin-Wah |
author_facet | Lau, Eunice Yuen-Ting Ho, Nicole Pui-Yu Lee, Terence Kin-Wah |
author_sort | Lau, Eunice Yuen-Ting |
collection | PubMed |
description | Tumor consists of heterogeneous cancer cells including cancer stem cells (CSCs) that can terminally differentiate into tumor bulk. Normal stem cells in normal organs regulate self-renewal within a stem cell niche. Likewise, accumulating evidence has also suggested that CSCs are maintained extrinsically within the tumor microenvironment, which includes both cellular and physical factors. Here, we review the significance of stromal cells, immune cells, extracellular matrix, tumor stiffness, and hypoxia in regulation of CSC plasticity and therapeutic resistance. With a better understanding of how CSC interacts with its niche, we are able to identify potential therapeutic targets for the development of more effective treatments against cancer. |
format | Online Article Text |
id | pubmed-5346399 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-53463992017-03-23 Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications Lau, Eunice Yuen-Ting Ho, Nicole Pui-Yu Lee, Terence Kin-Wah Stem Cells Int Review Article Tumor consists of heterogeneous cancer cells including cancer stem cells (CSCs) that can terminally differentiate into tumor bulk. Normal stem cells in normal organs regulate self-renewal within a stem cell niche. Likewise, accumulating evidence has also suggested that CSCs are maintained extrinsically within the tumor microenvironment, which includes both cellular and physical factors. Here, we review the significance of stromal cells, immune cells, extracellular matrix, tumor stiffness, and hypoxia in regulation of CSC plasticity and therapeutic resistance. With a better understanding of how CSC interacts with its niche, we are able to identify potential therapeutic targets for the development of more effective treatments against cancer. Hindawi Publishing Corporation 2017 2017-02-26 /pmc/articles/PMC5346399/ /pubmed/28337221 http://dx.doi.org/10.1155/2017/3714190 Text en Copyright © 2017 Eunice Yuen-Ting Lau et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lau, Eunice Yuen-Ting Ho, Nicole Pui-Yu Lee, Terence Kin-Wah Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications |
title | Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications |
title_full | Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications |
title_fullStr | Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications |
title_full_unstemmed | Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications |
title_short | Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications |
title_sort | cancer stem cells and their microenvironment: biology and therapeutic implications |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346399/ https://www.ncbi.nlm.nih.gov/pubmed/28337221 http://dx.doi.org/10.1155/2017/3714190 |
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