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Effective and Safe Use of Glucocorticosteroids for Rescue of Late ARDS

We describe a case of severe refractory hypoxemia requiring prolonged extra corporeal membrane oxygenation (ECMO) support in a case of postpartum acute respiratory distress syndrome (ARDS). The clinical course was marked by persistently poor lung compliance and several complications of ECMO, that is...

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Detalles Bibliográficos
Autores principales: Diana, Paolo, Money, Dustin T., Gelvin, Michael G., Lunardi, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346401/
https://www.ncbi.nlm.nih.gov/pubmed/28337348
http://dx.doi.org/10.1155/2017/6740532
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author Diana, Paolo
Money, Dustin T.
Gelvin, Michael G.
Lunardi, Nadia
author_facet Diana, Paolo
Money, Dustin T.
Gelvin, Michael G.
Lunardi, Nadia
author_sort Diana, Paolo
collection PubMed
description We describe a case of severe refractory hypoxemia requiring prolonged extra corporeal membrane oxygenation (ECMO) support in a case of postpartum acute respiratory distress syndrome (ARDS). The clinical course was marked by persistently poor lung compliance and several complications of ECMO, that is, significant hemolysis, hemothorax, and intracranial bleeding. We report marked improvement of lung mechanics and respiratory function, leading to accelerated separation from ECMO, following rescue administration of low dose methylprednisolone 24 days after the onset of ARDS. Corticosteroid treatment was safe and well tolerated. In contrast with the conclusions of the 2006 ARDS Network trial, our report establishes a case in support of the use of low dose methylprednisolone as a safe and effective rescue treatment option in selected subsets of patients with nonresolving ARDS.
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spelling pubmed-53464012017-03-23 Effective and Safe Use of Glucocorticosteroids for Rescue of Late ARDS Diana, Paolo Money, Dustin T. Gelvin, Michael G. Lunardi, Nadia Case Rep Crit Care Case Report We describe a case of severe refractory hypoxemia requiring prolonged extra corporeal membrane oxygenation (ECMO) support in a case of postpartum acute respiratory distress syndrome (ARDS). The clinical course was marked by persistently poor lung compliance and several complications of ECMO, that is, significant hemolysis, hemothorax, and intracranial bleeding. We report marked improvement of lung mechanics and respiratory function, leading to accelerated separation from ECMO, following rescue administration of low dose methylprednisolone 24 days after the onset of ARDS. Corticosteroid treatment was safe and well tolerated. In contrast with the conclusions of the 2006 ARDS Network trial, our report establishes a case in support of the use of low dose methylprednisolone as a safe and effective rescue treatment option in selected subsets of patients with nonresolving ARDS. Hindawi Publishing Corporation 2017 2017-02-26 /pmc/articles/PMC5346401/ /pubmed/28337348 http://dx.doi.org/10.1155/2017/6740532 Text en Copyright © 2017 Paolo Diana et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Diana, Paolo
Money, Dustin T.
Gelvin, Michael G.
Lunardi, Nadia
Effective and Safe Use of Glucocorticosteroids for Rescue of Late ARDS
title Effective and Safe Use of Glucocorticosteroids for Rescue of Late ARDS
title_full Effective and Safe Use of Glucocorticosteroids for Rescue of Late ARDS
title_fullStr Effective and Safe Use of Glucocorticosteroids for Rescue of Late ARDS
title_full_unstemmed Effective and Safe Use of Glucocorticosteroids for Rescue of Late ARDS
title_short Effective and Safe Use of Glucocorticosteroids for Rescue of Late ARDS
title_sort effective and safe use of glucocorticosteroids for rescue of late ards
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346401/
https://www.ncbi.nlm.nih.gov/pubmed/28337348
http://dx.doi.org/10.1155/2017/6740532
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