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The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?

The abscopal effect refers to the ability of localized radiation to trigger systemic antitumor effects. Over the past 50 years, reports on the abscopal effect arising from conventional radiation have been relatively rare. However, with the continued development and use of immunotherapy strategies in...

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Detalles Bibliográficos
Autores principales: Hu, Zishuo I., McArthur, Heather L., Ho, Alice Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346418/
https://www.ncbi.nlm.nih.gov/pubmed/28344743
http://dx.doi.org/10.1007/s12609-017-0234-y
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author Hu, Zishuo I.
McArthur, Heather L.
Ho, Alice Y.
author_facet Hu, Zishuo I.
McArthur, Heather L.
Ho, Alice Y.
author_sort Hu, Zishuo I.
collection PubMed
description The abscopal effect refers to the ability of localized radiation to trigger systemic antitumor effects. Over the past 50 years, reports on the abscopal effect arising from conventional radiation have been relatively rare. However, with the continued development and use of immunotherapy strategies incorporating radiotherapy with targeted immunomodulators and immune checkpoint blockade, the abscopal effect is becoming increasingly relevant in less immunogenic tumors such as breast cancer. Here, we review the mechanism of the abscopal effect, the current preclinical and clinical data, and the application of the abscopal effect in designing clinical trials of immunotherapy combined with radiotherapy in breast cancer.
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spelling pubmed-53464182017-03-24 The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer? Hu, Zishuo I. McArthur, Heather L. Ho, Alice Y. Curr Breast Cancer Rep Translational Research (TA King and EA Mittendorf, Section Editors) The abscopal effect refers to the ability of localized radiation to trigger systemic antitumor effects. Over the past 50 years, reports on the abscopal effect arising from conventional radiation have been relatively rare. However, with the continued development and use of immunotherapy strategies incorporating radiotherapy with targeted immunomodulators and immune checkpoint blockade, the abscopal effect is becoming increasingly relevant in less immunogenic tumors such as breast cancer. Here, we review the mechanism of the abscopal effect, the current preclinical and clinical data, and the application of the abscopal effect in designing clinical trials of immunotherapy combined with radiotherapy in breast cancer. Springer US 2017-03-02 2017 /pmc/articles/PMC5346418/ /pubmed/28344743 http://dx.doi.org/10.1007/s12609-017-0234-y Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Translational Research (TA King and EA Mittendorf, Section Editors)
Hu, Zishuo I.
McArthur, Heather L.
Ho, Alice Y.
The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?
title The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?
title_full The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?
title_fullStr The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?
title_full_unstemmed The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?
title_short The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?
title_sort abscopal effect of radiation therapy: what is it and how can we use it in breast cancer?
topic Translational Research (TA King and EA Mittendorf, Section Editors)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346418/
https://www.ncbi.nlm.nih.gov/pubmed/28344743
http://dx.doi.org/10.1007/s12609-017-0234-y
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