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Epithelial-Mesenchymal Transition of Ovarian Cancer Cells Is Sustained by Rac1 through Simultaneous Activation of MEK1/2 and Src Signaling Pathways

Epithelial-mesenchymal transition (EMT) is regarded as a crucial contributing factor to cancer progression. Diverse factors have been identified as potent EMT inducers in ovarian cancer. However, molecular mechanism sustaining EMT of ovarian cancer cells remains elusive. Here, we show that the prese...

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Detalles Bibliográficos
Autores principales: Fang, Dongdong, Chen, Huijun, Zhu, Jessica Y, Wang, Wei, Teng, Yong, Ding, Han-Fei, Jing, Qing, Su, Shi-Bing, Huang, Shuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346482/
https://www.ncbi.nlm.nih.gov/pubmed/27617576
http://dx.doi.org/10.1038/onc.2016.323