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Hypothalamic‐pituitary‐adrenal axis and depression symptom effects of an arginine vasopressin type 1B receptor antagonist in a one‐week randomized Phase 1b trial

BACKGROUND: Arginine vasopressin 1B receptor (V(1B)) antagonists may have utility for the treatment of major depressive disorder (MDD). METHODS: The V(1B) antagonist ABT‐436 (N = 31) or matching placebo (N = 20) was administered to MDD subjects for 7 days. The main study objectives were to assess th...

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Detalles Bibliográficos
Autores principales:	Katz, David A., Locke, Charles, Greco, Nicholas, Liu, Wei, Tracy, Katherine A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346517/ https://www.ncbi.nlm.nih.gov/pubmed/28293470 http://dx.doi.org/10.1002/brb3.628

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