Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression

Gastrointestinal stromal tumors (GIST) arise within the interstitial cell of Cajal (ICC) lineage due to activating KIT/PDGFRA mutations. Both ICC and GIST possess primary cilia (PC), which coordinate PDGFRA and Hedgehog signaling, regulators of gastrointestinal mesenchymal development. Therefore, we...

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Detalles Bibliográficos
Autores principales: Tang, Chih-Min, Lee, Tracy E., Syed, Sabriya A., Burgoyne, Adam M., Leonard, Stephanie Y., Gao, Fei, Chan, Jonathan C., Shi, Eileen, Chmielecki, Juliann, Morosini, Deborah, Wang, Kai, Ross, Jeffrey S., Kendrick, Michael L., Bardsley, Michael R., De Siena, Martina, Mao, Junhao, Harismendy, Olivier, Ordog, Tamas, Sicklick, Jason K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346634/
https://www.ncbi.nlm.nih.gov/pubmed/27793025
http://dx.doi.org/10.18632/oncotarget.12909

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