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Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1

Aggregation of proteins with the expansion of polyglutamine tracts in the brain underlies progressive genetic neurodegenerative diseases (NDs) like Huntington's disease and spinocerebellar ataxias (SCA). An insensitive cellular proteotoxic stress response to non-native protein oligomers is comm...

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Detalles Bibliográficos
Autores principales:	Nelson, Vinod K., Ali, Asif, Dutta, Naibedya, Ghosh, Suvranil, Jana, Manas, Ganguli, Arnab, Komarov, Andrei, Paul, Soumyadip, Dwivedi, Vibha, Chatterjee, Subhrangsu, Jana, Nihar R., Lakhotia, Subhash C., Chakrabarti, Gopal, Misra, Anup K., Mandal, Subhash C., Pal, Mahadeb
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346638/ https://www.ncbi.nlm.nih.gov/pubmed/27835876 http://dx.doi.org/10.18632/oncotarget.12930

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