Gene therapy with plasmids encoding IFN-β or IFN-α14 confers long-term resistance to HIV-1 in humanized mice

Because endogenous interferon type I (IFN-I) produced by HIV-1 infection might complicate the analysis of therapeutically administered IFN-I, we tested different humanized mouse models for induction of IFN-I during HIV-1 infection. While HIV-1 induced high levels of IFN-α in BLT mice, IFN-I was unde...

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Detalles Bibliográficos
Autores principales: Abraham, Sojan, Choi, Jang-Gi, Ortega, Nora M., Zhang, Junli, Shankar, Premlata, Swamy, N. Manjunath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346649/
https://www.ncbi.nlm.nih.gov/pubmed/27729616
http://dx.doi.org/10.18632/oncotarget.12512

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