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Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease
Resistin, belongs to cysteine-rich secretory protein, is mainly produced by circulating leukocytes, such as neutrophils monocytes and macrophages in humans. To date, few but controversial studies have reported about resistin concentrations in hyperthyroid patients, especially in Graves' disease...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346669/ https://www.ncbi.nlm.nih.gov/pubmed/27637079 http://dx.doi.org/10.18632/oncotarget.12019 |
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author | Peng, Ying Qi, Yicheng Huang, Fengjiao Chen, Xinxin Zhou, Yulin Ye, Lei Wang, Weiqing Ning, Guang Wang, Shu |
author_facet | Peng, Ying Qi, Yicheng Huang, Fengjiao Chen, Xinxin Zhou, Yulin Ye, Lei Wang, Weiqing Ning, Guang Wang, Shu |
author_sort | Peng, Ying |
collection | PubMed |
description | Resistin, belongs to cysteine-rich secretory protein, is mainly produced by circulating leukocytes, such as neutrophils monocytes and macrophages in humans. To date, few but controversial studies have reported about resistin concentrations in hyperthyroid patients, especially in Graves' disease (GD). We undertaked a controlled, prospective study to explore the serum resistin concentration in GD patients before and after -MMI treatment. In addition, we also investigated the main influencing factor on serum resistin level and discuessed the potential role of serum resistin plays in GD patients. 39 untreated GD (uGD) patients, including 8 males and 31 females, were enrolled in our investigation. All of these patients were prescribed with MMI treatment, in addition to 25 healthy controls. Anthropometric parameters and hormone assessment were measured. Enzyme-linked immunosorbent assay was used to detect serum resistin concentration in different stages of GD patients. Furthermore, neutrophil cell line NB4 with or without T3 treatment to detect the effect of thyroid hormones on resistin expression. The serum resistin level and neutrophil counts in untreated GD patients were significantly declined. And all of these parameters were recovered to normal after MMI treatment in ethyroid GD (eGD) and TRAb-negative conversion (nGD) patients. Resistin concentration exhibited a negative correlation with FT3 and FT4, but a positive correlation with absolute number of neutrophiles in uGD patients, whereas did not correlate with thyroid autoimmune antibodies and BMI. Neutrophile cell line, NB4, produced decreased expression of resistin when stimulated with T3. Our study showed a decrease of serum resistin level in GD patients and we suggested that the serum resistin might primarily secreted from circulating neutrophils and down-regulated by excessive thyroid hormones in GD patients. |
format | Online Article Text |
id | pubmed-5346669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53466692017-03-30 Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease Peng, Ying Qi, Yicheng Huang, Fengjiao Chen, Xinxin Zhou, Yulin Ye, Lei Wang, Weiqing Ning, Guang Wang, Shu Oncotarget Research Paper Resistin, belongs to cysteine-rich secretory protein, is mainly produced by circulating leukocytes, such as neutrophils monocytes and macrophages in humans. To date, few but controversial studies have reported about resistin concentrations in hyperthyroid patients, especially in Graves' disease (GD). We undertaked a controlled, prospective study to explore the serum resistin concentration in GD patients before and after -MMI treatment. In addition, we also investigated the main influencing factor on serum resistin level and discuessed the potential role of serum resistin plays in GD patients. 39 untreated GD (uGD) patients, including 8 males and 31 females, were enrolled in our investigation. All of these patients were prescribed with MMI treatment, in addition to 25 healthy controls. Anthropometric parameters and hormone assessment were measured. Enzyme-linked immunosorbent assay was used to detect serum resistin concentration in different stages of GD patients. Furthermore, neutrophil cell line NB4 with or without T3 treatment to detect the effect of thyroid hormones on resistin expression. The serum resistin level and neutrophil counts in untreated GD patients were significantly declined. And all of these parameters were recovered to normal after MMI treatment in ethyroid GD (eGD) and TRAb-negative conversion (nGD) patients. Resistin concentration exhibited a negative correlation with FT3 and FT4, but a positive correlation with absolute number of neutrophiles in uGD patients, whereas did not correlate with thyroid autoimmune antibodies and BMI. Neutrophile cell line, NB4, produced decreased expression of resistin when stimulated with T3. Our study showed a decrease of serum resistin level in GD patients and we suggested that the serum resistin might primarily secreted from circulating neutrophils and down-regulated by excessive thyroid hormones in GD patients. Impact Journals LLC 2016-09-14 /pmc/articles/PMC5346669/ /pubmed/27637079 http://dx.doi.org/10.18632/oncotarget.12019 Text en Copyright: © 2016 Peng et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Peng, Ying Qi, Yicheng Huang, Fengjiao Chen, Xinxin Zhou, Yulin Ye, Lei Wang, Weiqing Ning, Guang Wang, Shu Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease |
title | Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease |
title_full | Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease |
title_fullStr | Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease |
title_full_unstemmed | Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease |
title_short | Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease |
title_sort | down-regulated resistin level in consequence of decreased neutrophil counts in untreated grave's disease |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346669/ https://www.ncbi.nlm.nih.gov/pubmed/27637079 http://dx.doi.org/10.18632/oncotarget.12019 |
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