Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified

Microtubule targeting agents (MTAs) characteristically promote phosphorylation and degradation of Mcl-1, and this represents a critical pro-apoptotic signal in mitotic death. While several phosphorylation sites and kinases have been implicated in mitotic arrest-induced Mcl-1 phosphorylation, a compr...

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Detalles Bibliográficos
Autores principales: Chu, Rong, Alford, Sarah E., Hart, Katherine, Kothari, Anisha, Mackintosh, Samuel G., Kovak, Matthew R., Chambers, Timothy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346690/
https://www.ncbi.nlm.nih.gov/pubmed/27738316
http://dx.doi.org/10.18632/oncotarget.12586

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