DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation

Aberrant DNA methylation has been frequently observed in many human cancers, including rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children. To date, the expression and function of the de novo DNA methyltransferase (DNMT) 3B in RMS have not yet been investigated. Our study show fo...

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Detalles Bibliográficos
Autores principales: Megiorni, Francesca, Camero, Simona, Ceccarelli, Simona, McDowell, Heather P., Mannarino, Olga, Marampon, Francesco, Pizer, Barry, Shukla, Rajeev, Pizzuti, Antonio, Marchese, Cinzia, Clerico, Anna, Dominici, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346718/
https://www.ncbi.nlm.nih.gov/pubmed/27764816
http://dx.doi.org/10.18632/oncotarget.12688

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