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Association between miR-199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma
MicroRNAs (miRNAs) can regulate gene expression at post-transcriptional levels, thereby influence cancer risk. The aim of the current study is to investigate association between miR-199a rs74723057 and MET rs1621 and HCC risk in 1032 HCC patients and 1060 cancer-free controls. These two SNPs were ge...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346720/ https://www.ncbi.nlm.nih.gov/pubmed/27813498 http://dx.doi.org/10.18632/oncotarget.13033 |
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author | Wang, Qianqian Yu, Xiangyuan Li, Qiang Qin, Linyuan Tan, Shengkui Zeng, Xiaoyun Qiu, Xiaoqiang Tang, Bo Jin, Junfei Liao, Weijia Qiu, Moqin Tan, Lijun He, Gaofeng Li, Xiaomei He, Songqing Yu, Hongping |
author_facet | Wang, Qianqian Yu, Xiangyuan Li, Qiang Qin, Linyuan Tan, Shengkui Zeng, Xiaoyun Qiu, Xiaoqiang Tang, Bo Jin, Junfei Liao, Weijia Qiu, Moqin Tan, Lijun He, Gaofeng Li, Xiaomei He, Songqing Yu, Hongping |
author_sort | Wang, Qianqian |
collection | PubMed |
description | MicroRNAs (miRNAs) can regulate gene expression at post-transcriptional levels, thereby influence cancer risk. The aim of the current study is to investigate association between miR-199a rs74723057 and MET rs1621 and HCC risk in 1032 HCC patients and 1060 cancer-free controls. These two SNPs were genotyped by using the Agena MassARRAY genotyping system. Odds ratio (OR) and 95% confidence interval (95%CI) were calculated to assess the strength of the associations. We found that compared with the wild-type AA genotype of MET rs1621, the variant GG genotype was associated with a decreased risk for HCC (OR = 0.24, 95% CI = 0.06–0.96, P = 0.043). No association between miR-199a rs74723057 and HCC risk was observed. In addition, an interaction effect on HCC risk between the selected two SNPs was found. Among those who carried the CG/GG genotypes of miR-199a rs74723057, those who carried the GG genotype of MET rs1621 had a reduced risk of HCC, when compared with those who carried the AG/AA genotypes of MET rs1621 (OR = 0.15, 95% CI = 0.03~0.73, P for interaction = 0.018). Our results suggest that MET rs1621 polymorphism, alone and combined with miR-199a rs74723057, may influence susceptibility to HCC. Further large-scale association studies and functional studies are needed to validate our findings. |
format | Online Article Text |
id | pubmed-5346720 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53467202017-03-30 Association between miR-199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma Wang, Qianqian Yu, Xiangyuan Li, Qiang Qin, Linyuan Tan, Shengkui Zeng, Xiaoyun Qiu, Xiaoqiang Tang, Bo Jin, Junfei Liao, Weijia Qiu, Moqin Tan, Lijun He, Gaofeng Li, Xiaomei He, Songqing Yu, Hongping Oncotarget Research Paper MicroRNAs (miRNAs) can regulate gene expression at post-transcriptional levels, thereby influence cancer risk. The aim of the current study is to investigate association between miR-199a rs74723057 and MET rs1621 and HCC risk in 1032 HCC patients and 1060 cancer-free controls. These two SNPs were genotyped by using the Agena MassARRAY genotyping system. Odds ratio (OR) and 95% confidence interval (95%CI) were calculated to assess the strength of the associations. We found that compared with the wild-type AA genotype of MET rs1621, the variant GG genotype was associated with a decreased risk for HCC (OR = 0.24, 95% CI = 0.06–0.96, P = 0.043). No association between miR-199a rs74723057 and HCC risk was observed. In addition, an interaction effect on HCC risk between the selected two SNPs was found. Among those who carried the CG/GG genotypes of miR-199a rs74723057, those who carried the GG genotype of MET rs1621 had a reduced risk of HCC, when compared with those who carried the AG/AA genotypes of MET rs1621 (OR = 0.15, 95% CI = 0.03~0.73, P for interaction = 0.018). Our results suggest that MET rs1621 polymorphism, alone and combined with miR-199a rs74723057, may influence susceptibility to HCC. Further large-scale association studies and functional studies are needed to validate our findings. Impact Journals LLC 2016-11-02 /pmc/articles/PMC5346720/ /pubmed/27813498 http://dx.doi.org/10.18632/oncotarget.13033 Text en Copyright: © 2016 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Wang, Qianqian Yu, Xiangyuan Li, Qiang Qin, Linyuan Tan, Shengkui Zeng, Xiaoyun Qiu, Xiaoqiang Tang, Bo Jin, Junfei Liao, Weijia Qiu, Moqin Tan, Lijun He, Gaofeng Li, Xiaomei He, Songqing Yu, Hongping Association between miR-199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma |
title | Association between miR-199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma |
title_full | Association between miR-199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma |
title_fullStr | Association between miR-199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma |
title_full_unstemmed | Association between miR-199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma |
title_short | Association between miR-199a rs74723057 and MET rs1621 polymorphisms and the risk of hepatocellular carcinoma |
title_sort | association between mir-199a rs74723057 and met rs1621 polymorphisms and the risk of hepatocellular carcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346720/ https://www.ncbi.nlm.nih.gov/pubmed/27813498 http://dx.doi.org/10.18632/oncotarget.13033 |
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