Cargando…

KRAS-mutation status dependent effect of zoledronic acid in human non-small cell cancer preclinical models

BACKGROUND: In non-small cell lung cancer (NSCLC) KRAS-mutant status is a negative prognostic and predictive factor. Nitrogen-containing bisphosphonates inhibit prenylation of small G-proteins (e.g. Ras, Rac, Rho) and thus may affect proliferation and migration. In our preclinical work, we investiga...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kenessey, István, Kói, Krisztina, Horváth, Orsolya, Cserepes, Mihály, Molnár, Dávid, Izsák, Vera, Dobos, Judit, Hegedűs, Balázs, Tóvári, József, Tímár, József
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346731/ https://www.ncbi.nlm.nih.gov/pubmed/27780929 http://dx.doi.org/10.18632/oncotarget.12806

Ejemplares similares

Cell type-dependent HIF1 α-mediated effects of hypoxia on proliferation, migration and metastatic potential of human tumor cells
por: Tátrai, Enikő, et al.
Publicado: (2017)

Prenylation Inhibition-Induced Cell Death in Melanoma: Reduced Sensitivity in BRAF Mutant/PTEN Wild-Type Melanoma Cells
por: Garay, Tamás, et al.
Publicado: (2015)

EGFR Alterations Influence the Cetuximab Treatment Response and c-MET Tyrosine-Kinase Inhibitor Sensitivity in Experimental Head and Neck Squamous Cell Carcinomas
por: Nelhűbel, Györgyi A., et al.
Publicado: (2021)

KRAS-mutation incidence and prognostic value are metastatic site-specific in lung adenocarcinoma: poor prognosis in patients with KRAS mutation and bone metastasis
por: Lohinai, Zoltan, et al.
Publicado: (2017)

Horizontal Combination of MEK and PI3K/mTOR Inhibition in BRAF Mutant Tumor Cells with or without Concomitant PI3K Pathway Mutations
por: Rittler, Dominika, et al.
Publicado: (2020)

The Antitumor Effect of Lipophilic Bisphosphonate BPH1222 in Melanoma Models: The Role of the PI3K/Akt Pathway and the Small G Protein Rheb
por: Rittler, Dominika, et al.
Publicado: (2019)

EGFR R521K Polymorphism Is Not a Major Determinant of Clinical Cetuximab Resistance in Head and Neck Cancer
por: Cserepes, Mihály, et al.
Publicado: (2022)

EGFR Protein Expression in KRAS Wild-Type Metastatic Colorectal Cancer Is Another Negative Predictive Factor of the Cetuximab Therapy
por: Uhlyarik, Andrea, et al.
Publicado: (2020)

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells
por: Molnár, Eszter, et al.
Publicado: (2018)

Evolving Acquired Vemurafenib Resistance in a BRAF V600E Mutant Melanoma PDTX Model to Reveal New Potential Targets
por: Tóvári, József, et al.
Publicado: (2023)

The effects of bisphosphonate and radiation therapy in bone-metastatic lung adenocarcinoma: the impact of KRAS mutation
por: Radeczky, Peter, et al.
Publicado: (2021)

Histone Deacetylase Inhibitor Treatment Increases the Expression of the Plasma Membrane Ca(2+) Pump PMCA4b and Inhibits the Migration of Melanoma Cells Independent of ERK
por: Hegedüs, Luca, et al.
Publicado: (2017)

Erythropoietin Receptor Expression Is a Potential Prognostic Factor in Human Lung Adenocarcinoma
por: Rózsás, Anita, et al.
Publicado: (2013)

Molecular epidemiology and diagnostics of KRAS mutations in human cancer
por: Timar, Jozsef, et al.
Publicado: (2020)

P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b
por: Naffa, Randa, et al.
Publicado: (2020)

A Comparative Study of the Role of Formins in Drosophila Embryonic Dorsal Closure
por: Tóth, Krisztina, et al.
Publicado: (2022)

KRAS Mutations Predict Response and Outcome in Advanced Lung Adenocarcinoma Patients Receiving First-Line Bevacizumab and Platinum-Based Chemotherapy
por: Ghimessy, Áron Kristof, et al.
Publicado: (2019)

Role of retinoic receptors in lung carcinogenesis
por: Bogos, Krisztina, et al.
Publicado: (2008)

A Novel C-Type Lectin Receptor-Targeted α-Synuclein-Based Parkinson Vaccine Induces Potent Immune Responses and Therapeutic Efficacy in Mice
por: Schmidhuber, Sabine, et al.
Publicado: (2022)

Long-Term Dynamic Changes in Cosmetic Outcomes and Patient Satisfaction after Implant-Based Postmastectomy Breast Reconstruction and Contralateral Mastopexy with or without an Ultrapro Mesh Sling Used for the Inner Bra Technique. A Retrospective Correlational Study
por: József, Zsófia, et al.
Publicado: (2020)

Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma: Increased Cell Migration and Its Association with EGFR Expression
por: Molnár, Eszter, et al.
Publicado: (2019)

Allosteric and ATP-Competitive MEK-Inhibition in a Novel Spitzoid Melanoma Model with a RAF- and Phosphorylation-Independent Mutation
por: Hegedüs, Luca, et al.
Publicado: (2021)

The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction–dependent manner
por: Keller-Pinter, Aniko, et al.
Publicado: (2017)

Ligand entry in human ileal bile acid-binding protein is mediated by histidine protonation
por: Horváth, Gergő, et al.
Publicado: (2019)

Microcirculatory consequences of limb ischemia/reperfusion in ovariectomized rats treated with zoledronic acid
por: Pócs, Levente, et al.
Publicado: (2019)

Signaling Pathways Mediating Bradykinin-Induced Contraction in Murine and Human Detrusor Muscle
por: Borsodi, Kinga, et al.
Publicado: (2022)

Combination therapy with zoledronic acid and cetuximab effectively suppresses growth of colorectal cancer cells regardless of KRAS status
por: Kato, Junko, et al.
Publicado: (2016)

A user-friendly, high-throughput tool for the precise fluorescent quantification of deoxyribonucleoside triphosphates from biological samples
por: Szabó, Judit Eszter, et al.
Publicado: (2020)

A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures
por: Diossy, Miklos, et al.
Publicado: (2021)

Improved in vivo antitumor effect of a daunorubicin - GnRH-III bioconjugate modified by apoptosis inducing agent butyric acid on colorectal carcinoma bearing mice
por: Kapuvári, Bence, et al.
Publicado: (2016)

Apelin promotes lymphangiogenesis and lymph node metastasis
por: Berta, Judit, et al.
Publicado: (2014)

Formin’ bridges between microtubules and actin filaments in axonal growth cones
por: Földi, István, et al.
Publicado: (2017)

Potential role of the ABCG2-Q141K polymorphism in type 2 diabetes
por: Szabó, Edit, et al.
Publicado: (2021)

Nationwide Effectiveness of First and Second SARS-CoV2 Booster Vaccines During the Delta and Omicron Pandemic Waves in Hungary (HUN-VE 2 Study)
por: Kiss, Zoltán, et al.
Publicado: (2022)

Effectiveness and Waning of Protection With Different SARS-CoV-2 Primary and Booster Vaccines During the Delta Pandemic Wave in 2021 in Hungary (HUN-VE 3 Study)
por: Vokó, Zoltán, et al.
Publicado: (2022)

Current therapy of KRAS-mutant lung cancer
por: Ghimessy, Aron, et al.
Publicado: (2020)

Molecular Dissection of DAAM Function during Axon Growth in Drosophila Embryonic Neurons
por: Földi, István, et al.
Publicado: (2022)

Mutations of KRAS, NRAS, BRAF, EGFR, and PIK3CA genes in urachal carcinoma: Occurence and prognostic significance
por: Módos, Orsolya, et al.
Publicado: (2016)

The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma
por: Laszlo, Viktoria, et al.
Publicado: (2018)

Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimer’s Disease: From In Silico to In Vivo
por: Stern, Noa, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hl8kagubb9uicsfgqirb4v5vc1