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Blood Sampling Seasonality as an Important Preanalytical Factor for Assessment of Vitamin D Status

BACKGROUND: The measurement of vitamin D is now commonplace for preventing osteoporosis and restoring an appropriate concentration that would be effective to counteract the occurrence of other human disorders. The aim of this study was to establish whether blood sampling seasonality may influence to...

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Autores principales: Bonelli, Patrizia, Buonocore, Ruggero, Aloe, Rosalia, Lippi, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Medical Biochemists of Serbia 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346786/
https://www.ncbi.nlm.nih.gov/pubmed/28356869
http://dx.doi.org/10.1515/jomb-2015-0014
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author Bonelli, Patrizia
Buonocore, Ruggero
Aloe, Rosalia
Lippi, Giuseppe
author_facet Bonelli, Patrizia
Buonocore, Ruggero
Aloe, Rosalia
Lippi, Giuseppe
author_sort Bonelli, Patrizia
collection PubMed
description BACKGROUND: The measurement of vitamin D is now commonplace for preventing osteoporosis and restoring an appropriate concentration that would be effective to counteract the occurrence of other human disorders. The aim of this study was to establish whether blood sampling seasonality may influence total vitamin D concentration in a general population of Italian unselected outpatients. METHODS: We performed a retrospective search in the laboratory information system of the University Hospital of Parma (Italy, temperate climate), to identify the values of total serum vitamin D (25-hydroxyvitamin D) measured in outpatients aged 18 years and older, who were referred for routine health check-up during the entire year 2014. RESULTS: The study population consisted in 11,150 outpatients (median age 62 years; 8592 women and 2558 men). The concentration of vitamin D was consistently lower in samples collected in Winter than in the other three seasons. The frequency of subjects with vitamin D deficiency was approximately double in samples drawn in Winter and Spring than in Summer and Autumn. In the multivariate analysis, the concentration of total vitamin D was found to be independently associated with sex and season of blood testing, but not with the age of the patients. CONCLUSIONS: According to these findings, blood sampling seasonality should be regarded as an important preanalytical factor in vitamin D assessment. It is also reasonable to suggest that the amount of total vitamin D synthesized during the summer should be high enough to maintain the levels > 50 nmol/L throughout the remaining part of the year.
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spelling pubmed-53467862017-03-29 Blood Sampling Seasonality as an Important Preanalytical Factor for Assessment of Vitamin D Status Bonelli, Patrizia Buonocore, Ruggero Aloe, Rosalia Lippi, Giuseppe J Med Biochem Original Paper BACKGROUND: The measurement of vitamin D is now commonplace for preventing osteoporosis and restoring an appropriate concentration that would be effective to counteract the occurrence of other human disorders. The aim of this study was to establish whether blood sampling seasonality may influence total vitamin D concentration in a general population of Italian unselected outpatients. METHODS: We performed a retrospective search in the laboratory information system of the University Hospital of Parma (Italy, temperate climate), to identify the values of total serum vitamin D (25-hydroxyvitamin D) measured in outpatients aged 18 years and older, who were referred for routine health check-up during the entire year 2014. RESULTS: The study population consisted in 11,150 outpatients (median age 62 years; 8592 women and 2558 men). The concentration of vitamin D was consistently lower in samples collected in Winter than in the other three seasons. The frequency of subjects with vitamin D deficiency was approximately double in samples drawn in Winter and Spring than in Summer and Autumn. In the multivariate analysis, the concentration of total vitamin D was found to be independently associated with sex and season of blood testing, but not with the age of the patients. CONCLUSIONS: According to these findings, blood sampling seasonality should be regarded as an important preanalytical factor in vitamin D assessment. It is also reasonable to suggest that the amount of total vitamin D synthesized during the summer should be high enough to maintain the levels > 50 nmol/L throughout the remaining part of the year. Society of Medical Biochemists of Serbia 2016-04 2016-05-09 /pmc/articles/PMC5346786/ /pubmed/28356869 http://dx.doi.org/10.1515/jomb-2015-0014 Text en © 2016 Patrizia Bonelli et al., published by De Gruyter Open http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
spellingShingle Original Paper
Bonelli, Patrizia
Buonocore, Ruggero
Aloe, Rosalia
Lippi, Giuseppe
Blood Sampling Seasonality as an Important Preanalytical Factor for Assessment of Vitamin D Status
title Blood Sampling Seasonality as an Important Preanalytical Factor for Assessment of Vitamin D Status
title_full Blood Sampling Seasonality as an Important Preanalytical Factor for Assessment of Vitamin D Status
title_fullStr Blood Sampling Seasonality as an Important Preanalytical Factor for Assessment of Vitamin D Status
title_full_unstemmed Blood Sampling Seasonality as an Important Preanalytical Factor for Assessment of Vitamin D Status
title_short Blood Sampling Seasonality as an Important Preanalytical Factor for Assessment of Vitamin D Status
title_sort blood sampling seasonality as an important preanalytical factor for assessment of vitamin d status
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346786/
https://www.ncbi.nlm.nih.gov/pubmed/28356869
http://dx.doi.org/10.1515/jomb-2015-0014
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