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Non-Coding RNAs: New Players in Skin Wound Healing
Significance: Wound healing is a basic physiological process that is utilized to keep the integrity of the skin. Impaired wound repair, such as chronic wounds and pathological scars, presents a major health and economic burden worldwide. To date, efficient targeted treatment for these wound disorder...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346954/ https://www.ncbi.nlm.nih.gov/pubmed/28289554 http://dx.doi.org/10.1089/wound.2016.0711 |
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author | Herter, Eva K. Xu Landén, Ning |
author_facet | Herter, Eva K. Xu Landén, Ning |
author_sort | Herter, Eva K. |
collection | PubMed |
description | Significance: Wound healing is a basic physiological process that is utilized to keep the integrity of the skin. Impaired wound repair, such as chronic wounds and pathological scars, presents a major health and economic burden worldwide. To date, efficient targeted treatment for these wound disorders is still lacking, which is largely due to our limited understanding of the biological mechanisms underlying these diseases. Research driven around discovering new therapies for these complications is, therefore, an urgent need. Recent Advances: The vast majority of the human genome is transcribed to RNAs that lack protein-coding capacity. Intensive research in the recent decade has revealed that these non-coding RNAs (ncRNAs) function as important regulators of cellular physiology and pathology, which makes them promising therapeutic and diagnostic entities. Critical Issues: A class of short ncRNAs, microRNAs, has been found to be indispensable for all the phases of skin wound healing and plays important roles in the pathogenesis of wound complications. The role of long ncRNAs (lncRNA) in skin wound healing remains largely unexplored. Recent studies revealed the essential role of lncRNAs in epidermal differentiation and stress response, indicating their potential importance for skin wound healing, which warrants future research. Future Directions: An investigation of ncRNAs will add new layers of complexity to our understanding of normal skin wound healing as well as to the pathogenesis of wound disorders. Development of ncRNA-based biomarkers and treatments is an interesting and important avenue for future research on wound healing. |
format | Online Article Text |
id | pubmed-5346954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Mary Ann Liebert, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-53469542017-03-13 Non-Coding RNAs: New Players in Skin Wound Healing Herter, Eva K. Xu Landén, Ning Adv Wound Care (New Rochelle) Comprehensive Invited Review Significance: Wound healing is a basic physiological process that is utilized to keep the integrity of the skin. Impaired wound repair, such as chronic wounds and pathological scars, presents a major health and economic burden worldwide. To date, efficient targeted treatment for these wound disorders is still lacking, which is largely due to our limited understanding of the biological mechanisms underlying these diseases. Research driven around discovering new therapies for these complications is, therefore, an urgent need. Recent Advances: The vast majority of the human genome is transcribed to RNAs that lack protein-coding capacity. Intensive research in the recent decade has revealed that these non-coding RNAs (ncRNAs) function as important regulators of cellular physiology and pathology, which makes them promising therapeutic and diagnostic entities. Critical Issues: A class of short ncRNAs, microRNAs, has been found to be indispensable for all the phases of skin wound healing and plays important roles in the pathogenesis of wound complications. The role of long ncRNAs (lncRNA) in skin wound healing remains largely unexplored. Recent studies revealed the essential role of lncRNAs in epidermal differentiation and stress response, indicating their potential importance for skin wound healing, which warrants future research. Future Directions: An investigation of ncRNAs will add new layers of complexity to our understanding of normal skin wound healing as well as to the pathogenesis of wound disorders. Development of ncRNA-based biomarkers and treatments is an interesting and important avenue for future research on wound healing. Mary Ann Liebert, Inc. 2017-03-01 2017-03-01 /pmc/articles/PMC5346954/ /pubmed/28289554 http://dx.doi.org/10.1089/wound.2016.0711 Text en © Eva K. Herter and Ning Xu Landén, 2017; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Comprehensive Invited Review Herter, Eva K. Xu Landén, Ning Non-Coding RNAs: New Players in Skin Wound Healing |
title | Non-Coding RNAs: New Players in Skin Wound Healing |
title_full | Non-Coding RNAs: New Players in Skin Wound Healing |
title_fullStr | Non-Coding RNAs: New Players in Skin Wound Healing |
title_full_unstemmed | Non-Coding RNAs: New Players in Skin Wound Healing |
title_short | Non-Coding RNAs: New Players in Skin Wound Healing |
title_sort | non-coding rnas: new players in skin wound healing |
topic | Comprehensive Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346954/ https://www.ncbi.nlm.nih.gov/pubmed/28289554 http://dx.doi.org/10.1089/wound.2016.0711 |
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