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Evolutionary Covariance Combined with Molecular Dynamics Predicts a Framework for Allostery in the MutS DNA Mismatch Repair Protein

[Image: see text] Mismatch repair (MMR) is an essential, evolutionarily conserved pathway that maintains genome stability by correcting base-pairing errors in DNA. Here we examine the sequence and structure of MutS MMR protein to decipher the amino acid framework underlying its two key activities—re...

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Detalles Bibliográficos
Autores principales:	Lakhani, Bharat, Thayer, Kelly M., Hingorani, Manju M., Beveridge, David L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346969/ https://www.ncbi.nlm.nih.gov/pubmed/28135092 http://dx.doi.org/10.1021/acs.jpcb.6b11976

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