The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression

Tyrosine kinase signalling within cancer cells is central to the establishment of an immunosuppressive microenvironment. Although tyrosine kinase inhibitors act, in part, to augment adaptive immunity, the increased heterogeneity and functional redundancy of the tyrosine kinome is a hurdle to achievi...

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Detalles Bibliográficos
Autores principales: Ahn, Ryuhjin, Sabourin, Valérie, Bolt, Alicia M., Hébert, Steven, Totten, Stephanie, De Jay, Nicolas, Festa, Maria Carolina, Young, Yoon Kow, Im, Young Kyuen, Pawson, Tony, Koromilas, Antonis E., Muller, William J., Mann, Koren K., Kleinman, Claudia L., Ursini-Siegel, Josie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347092/
https://www.ncbi.nlm.nih.gov/pubmed/28276425
http://dx.doi.org/10.1038/ncomms14638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347092/
https://www.ncbi.nlm.nih.gov/pubmed/28276425
http://dx.doi.org/10.1038/ncomms14638

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