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Loss of Centromere Cohesion in Aneuploid Human Oocytes Correlates with Decreased Kinetochore Localization of the Sac Proteins Bub1 and Bubr1

In human eggs, aneuploidy increases with age and can result in infertility and genetic diseases. Studies in mouse oocytes suggest that reduced centromere cohesion and spindle assembly checkpoint (SAC) activity could be at the origin of chromosome missegregation. Little is known about these two featu...

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Detalles Bibliográficos
Autores principales:	Lagirand-Cantaloube, Julie, Ciabrini, Cendrine, Charrasse, Sophie, Ferrieres, Alice, Castro, Anna, Anahory, Tal, Lorca, Thierry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347135/ https://www.ncbi.nlm.nih.gov/pubmed/28287092 http://dx.doi.org/10.1038/srep44001

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