TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT

Intrinsic and acquired resistance to chemotherapy is the fundamental reason for treatment failure for many cancer patients. The identification of molecular mechanisms involved in drug resistance or sensitization is imperative. Here we report that tribbles homologue 2 (TRIB2) ablates forkhead box O a...

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Detalles Bibliográficos
Autores principales: Hill, Richard, Madureira, Patricia A., Ferreira, Bibiana, Baptista, Inês, Machado, Susana, Colaço, Laura, dos Santos, Marta, Liu, Ningshu, Dopazo, Ana, Ugurel, Selma, Adrienn, Angyal, Kiss-Toth, Endre, Isbilen, Murat, Gure, Ali O., Link, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347136/
https://www.ncbi.nlm.nih.gov/pubmed/28276427
http://dx.doi.org/10.1038/ncomms14687

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