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RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

Long-lived organisms often feature more stringent protein and DNA quality control. However, whether RNA quality control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both abnormal as well as some normal transcripts, have a role in organismal aging remains unexplored. Here we...

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Detalles Bibliográficos
Autores principales:	Son, Heehwa G., Seo, Mihwa, Ham, Seokjin, Hwang, Wooseon, Lee, Dongyeop, An, Seon Woo A., Artan, Murat, Seo, Keunhee, Kaletsky, Rachel, Arey, Rachel N., Ryu, Youngjae, Ha, Chang Man, Kim, Yoon Ki, Murphy, Coleen T., Roh, Tae-Young, Nam, Hong Gil, Lee, Seung-Jae V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347137/ https://www.ncbi.nlm.nih.gov/pubmed/28276441 http://dx.doi.org/10.1038/ncomms14749

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