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Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency

We showed previously that the histone lysine methyltransferase (HKMT) H3K27me3 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and is required for the maintenance of HIV-1 latency in Jurkat T cells. Here we show, by using chromatin immunoprecipitation experiments, that both P...

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Detalles Bibliográficos
Autores principales:	Nguyen, Kien, Das, Biswajit, Dobrowolski, Curtis, Karn, Jonathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347344/ https://www.ncbi.nlm.nih.gov/pubmed/28246360 http://dx.doi.org/10.1128/mBio.00133-17

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