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Interleukin-28B rs12979860 C/T Polymorphism and Acute Cellular Rejection after Liver Transplantation

BACKGROUND: Interleukin-28 (IL-28B) rs12979860 C/T polymorphism is a known predictor of sustained virological response after antiviral treatment in hepatitis C. IL-28B affects the innate immune system as well as intrahepatic expression level of interferon-stimulated genes. OBJECTIVE: To investigate...

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Autores principales: Fereidooni, H., Azarpira, N., Yaghobi, R., Vahdati, A., Malek-Hoseini, S. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Organ Transplantation Institute 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347403/
https://www.ncbi.nlm.nih.gov/pubmed/28299025
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author Fereidooni, H.
Azarpira, N.
Yaghobi, R.
Vahdati, A.
Malek-Hoseini, S. A.
author_facet Fereidooni, H.
Azarpira, N.
Yaghobi, R.
Vahdati, A.
Malek-Hoseini, S. A.
author_sort Fereidooni, H.
collection PubMed
description BACKGROUND: Interleukin-28 (IL-28B) rs12979860 C/T polymorphism is a known predictor of sustained virological response after antiviral treatment in hepatitis C. IL-28B affects the innate immune system as well as intrahepatic expression level of interferon-stimulated genes. OBJECTIVE: To investigate the effect of recipient IL-28B polymorphism on occurrence of acute rejection after liver transplantation. METHODS: 140 liver allograft recipients were selected. Acute rejection episodes were recorded in 39 patients (AR group); the remaining had normal graft function (non-AR group). 70 normal subjects were also studied as the control group. The IL-28B rs12979860 was genotyped through PCR-RFLP method. RESULTS: No significant difference was found between AR and non-AR groups in terms of genotype and allele frequency. However, the CC genotype was significantly (p<0.001) more frequent in patients than in the control group; the C allele variants increased the risk of end-stage liver disease (OR: 2.60). CONCLUSION: Liver damage in association with the carriage of IL-28B C allele is associated with a higher likelihood of developing cirrhosis.
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spelling pubmed-53474032017-03-15 Interleukin-28B rs12979860 C/T Polymorphism and Acute Cellular Rejection after Liver Transplantation Fereidooni, H. Azarpira, N. Yaghobi, R. Vahdati, A. Malek-Hoseini, S. A. Int J Organ Transplant Med Original Article BACKGROUND: Interleukin-28 (IL-28B) rs12979860 C/T polymorphism is a known predictor of sustained virological response after antiviral treatment in hepatitis C. IL-28B affects the innate immune system as well as intrahepatic expression level of interferon-stimulated genes. OBJECTIVE: To investigate the effect of recipient IL-28B polymorphism on occurrence of acute rejection after liver transplantation. METHODS: 140 liver allograft recipients were selected. Acute rejection episodes were recorded in 39 patients (AR group); the remaining had normal graft function (non-AR group). 70 normal subjects were also studied as the control group. The IL-28B rs12979860 was genotyped through PCR-RFLP method. RESULTS: No significant difference was found between AR and non-AR groups in terms of genotype and allele frequency. However, the CC genotype was significantly (p<0.001) more frequent in patients than in the control group; the C allele variants increased the risk of end-stage liver disease (OR: 2.60). CONCLUSION: Liver damage in association with the carriage of IL-28B C allele is associated with a higher likelihood of developing cirrhosis. Avicenna Organ Transplantation Institute 2017 2017-02-01 /pmc/articles/PMC5347403/ /pubmed/28299025 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Fereidooni, H.
Azarpira, N.
Yaghobi, R.
Vahdati, A.
Malek-Hoseini, S. A.
Interleukin-28B rs12979860 C/T Polymorphism and Acute Cellular Rejection after Liver Transplantation
title Interleukin-28B rs12979860 C/T Polymorphism and Acute Cellular Rejection after Liver Transplantation
title_full Interleukin-28B rs12979860 C/T Polymorphism and Acute Cellular Rejection after Liver Transplantation
title_fullStr Interleukin-28B rs12979860 C/T Polymorphism and Acute Cellular Rejection after Liver Transplantation
title_full_unstemmed Interleukin-28B rs12979860 C/T Polymorphism and Acute Cellular Rejection after Liver Transplantation
title_short Interleukin-28B rs12979860 C/T Polymorphism and Acute Cellular Rejection after Liver Transplantation
title_sort interleukin-28b rs12979860 c/t polymorphism and acute cellular rejection after liver transplantation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347403/
https://www.ncbi.nlm.nih.gov/pubmed/28299025
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