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Sperm Retrieval in Patients with Klinefelter Syndrome: A Skewed Regression Model Analysis
BACKGROUND: The most common chromosomal abnormality due to non-obstructive azoospermia (NOA) is Klinefelter syndrome (KS) which occurs in 1-1.72 out of 500-1000 male infants. The probability of retrieving sperm as the outcome could be asymmetrically different between patients with and without KS, th...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347449/ https://www.ncbi.nlm.nih.gov/pubmed/28670430 http://dx.doi.org/10.22074/ijfs.2017.4702 |
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author | Chehrazi, Mohammad Rahimiforoushani, Abbas Sabbaghian, Marjan Nourijelyani, Keramat Sadighi Gilani, Mohammad Ali Hoseini, Mostafa Vesali, Samira Yaseri, Mehdi Alizadeh, Ahad Mohammad, Kazem Samani, Reza Omani |
author_facet | Chehrazi, Mohammad Rahimiforoushani, Abbas Sabbaghian, Marjan Nourijelyani, Keramat Sadighi Gilani, Mohammad Ali Hoseini, Mostafa Vesali, Samira Yaseri, Mehdi Alizadeh, Ahad Mohammad, Kazem Samani, Reza Omani |
author_sort | Chehrazi, Mohammad |
collection | PubMed |
description | BACKGROUND: The most common chromosomal abnormality due to non-obstructive azoospermia (NOA) is Klinefelter syndrome (KS) which occurs in 1-1.72 out of 500-1000 male infants. The probability of retrieving sperm as the outcome could be asymmetrically different between patients with and without KS, therefore logistic regression analysis is not a well-qualified test for this type of data. This study has been designed to evaluate skewed regression model analysis for data collected from microsurgical testicular sperm extraction (micro-TESE) among azoospermic patients with and without non-mosaic KS syndrome. MATERIALS AND METHODS: This cohort study compared the micro-TESE outcome between 134 men with classic KS and 537 men with NOA and normal karyotype who were referred to Royan Institute between 2009 and 2011. In addition to our main outcome, which was sperm retrieval, we also used logistic and skewed regression analyses to compare the following demographic and hormonal factors: age, level of follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone between the two groups. RESULTS: A comparison of the micro-TESE between the KS and control groups showed a success rate of 28.4% (38/134) for the KS group and 22.2% (119/537) for the control group. In the KS group, a significantly difference (P<0.001) existed between testosterone levels for the successful sperm retrieval group (3.4 ± 0.48 mg/mL) compared to the unsuccessful sperm retrieval group (2.33 ± 0.23 mg/mL). The index for quasi Akaike information criterion (QAIC) had a goodness of fit of 74 for the skewed model which was lower than logistic regression (QAIC=85). CONCLUSION: According to the results, skewed regression is more efficient in estimating sperm retrieval success when the data from patients with KS are analyzed. This finding should be investigated by conducting additional studies with different data structures. |
format | Online Article Text |
id | pubmed-5347449 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-53474492017-07-01 Sperm Retrieval in Patients with Klinefelter Syndrome: A Skewed Regression Model Analysis Chehrazi, Mohammad Rahimiforoushani, Abbas Sabbaghian, Marjan Nourijelyani, Keramat Sadighi Gilani, Mohammad Ali Hoseini, Mostafa Vesali, Samira Yaseri, Mehdi Alizadeh, Ahad Mohammad, Kazem Samani, Reza Omani Int J Fertil Steril Original Article BACKGROUND: The most common chromosomal abnormality due to non-obstructive azoospermia (NOA) is Klinefelter syndrome (KS) which occurs in 1-1.72 out of 500-1000 male infants. The probability of retrieving sperm as the outcome could be asymmetrically different between patients with and without KS, therefore logistic regression analysis is not a well-qualified test for this type of data. This study has been designed to evaluate skewed regression model analysis for data collected from microsurgical testicular sperm extraction (micro-TESE) among azoospermic patients with and without non-mosaic KS syndrome. MATERIALS AND METHODS: This cohort study compared the micro-TESE outcome between 134 men with classic KS and 537 men with NOA and normal karyotype who were referred to Royan Institute between 2009 and 2011. In addition to our main outcome, which was sperm retrieval, we also used logistic and skewed regression analyses to compare the following demographic and hormonal factors: age, level of follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone between the two groups. RESULTS: A comparison of the micro-TESE between the KS and control groups showed a success rate of 28.4% (38/134) for the KS group and 22.2% (119/537) for the control group. In the KS group, a significantly difference (P<0.001) existed between testosterone levels for the successful sperm retrieval group (3.4 ± 0.48 mg/mL) compared to the unsuccessful sperm retrieval group (2.33 ± 0.23 mg/mL). The index for quasi Akaike information criterion (QAIC) had a goodness of fit of 74 for the skewed model which was lower than logistic regression (QAIC=85). CONCLUSION: According to the results, skewed regression is more efficient in estimating sperm retrieval success when the data from patients with KS are analyzed. This finding should be investigated by conducting additional studies with different data structures. Royan Institute 2017 2017-02-16 /pmc/articles/PMC5347449/ /pubmed/28670430 http://dx.doi.org/10.22074/ijfs.2017.4702 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chehrazi, Mohammad Rahimiforoushani, Abbas Sabbaghian, Marjan Nourijelyani, Keramat Sadighi Gilani, Mohammad Ali Hoseini, Mostafa Vesali, Samira Yaseri, Mehdi Alizadeh, Ahad Mohammad, Kazem Samani, Reza Omani Sperm Retrieval in Patients with Klinefelter Syndrome: A Skewed Regression Model Analysis |
title | Sperm Retrieval in Patients with Klinefelter Syndrome:
A Skewed Regression Model Analysis |
title_full | Sperm Retrieval in Patients with Klinefelter Syndrome:
A Skewed Regression Model Analysis |
title_fullStr | Sperm Retrieval in Patients with Klinefelter Syndrome:
A Skewed Regression Model Analysis |
title_full_unstemmed | Sperm Retrieval in Patients with Klinefelter Syndrome:
A Skewed Regression Model Analysis |
title_short | Sperm Retrieval in Patients with Klinefelter Syndrome:
A Skewed Regression Model Analysis |
title_sort | sperm retrieval in patients with klinefelter syndrome:
a skewed regression model analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347449/ https://www.ncbi.nlm.nih.gov/pubmed/28670430 http://dx.doi.org/10.22074/ijfs.2017.4702 |
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