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Kisspeptin: A Potential Factor for Unexplained Infertility and Impaired Embryo Implantation

BACKGROUND: Kisspeptin (KP) is a neuropeptide that causes the release of the gonadotropin releasing hormone, which controls hypothalamo pituitary ovarian axis and exerts a number of peripheral effects on reproductive organs. The primary objective of this study was to compare baseline KP levels in fe...

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Autores principales: Mumtaz, Aaida, Khalid, Aqsa, Jamil, Zehra, Fatima, Syeda Sadia, Arif, Sara, Rehman, Rehana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347457/
https://www.ncbi.nlm.nih.gov/pubmed/28670427
http://dx.doi.org/10.22074/ijfs.2017.4957
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author Mumtaz, Aaida
Khalid, Aqsa
Jamil, Zehra
Fatima, Syeda Sadia
Arif, Sara
Rehman, Rehana
author_facet Mumtaz, Aaida
Khalid, Aqsa
Jamil, Zehra
Fatima, Syeda Sadia
Arif, Sara
Rehman, Rehana
author_sort Mumtaz, Aaida
collection PubMed
description BACKGROUND: Kisspeptin (KP) is a neuropeptide that causes the release of the gonadotropin releasing hormone, which controls hypothalamo pituitary ovarian axis and exerts a number of peripheral effects on reproductive organs. The primary objective of this study was to compare baseline KP levels in females with different types of infertility and identify possible correlations with risk of failure to conceive, preclinical abortion and pregnancy after intracytoplasmic sperm injection (ICSI). MATERIALS AND METHODS: A longitudinal cohort study was carried out from August 2014 until May 2015 by recruiting 124 female patients undergoing ICSI, after obtaining ethical approval from the Australian Concept Infertility Medical Center. Cause of infertility due to male, female and unexplained factors was at a frequency of 32 (24%), 33 (31%) and 59 (45%) among the individuals respectively. KP levels were measured by ELISA assay before the initiation of the ICSI treatment protocol. Outcome of ICSI was categorized into three groups of non-pregnant with beta-human chorionic gonadotropin (β-hCG)<5-25 mIU/ml, preclinical abortion with β-hCG>25 mIU/ml and no cardiac activity, and clinical pregnancy declared upon confirmation of cardiac activity. Results based on cause of infertility and outcome groups were analyzed by one-way ANOVA. RESULTS: Females with unexplained infertility had significantly lower levels of KP when compared with those with male factor infertility (176.69 ± 5.03 vs. 397.6 ± 58.2, P=0.001). Clinical pregnancy was observed in 28 (23%) females of which 17 (71%) had a female cause of infertility. In the non-pregnant group of 66 (53%) females, common cause of infertility was unexplained 56(85%). A weak positive correlation of KP levels with fertilized oocytes and endometrial thickness was observed (P=0.04 and 0.01 respectively). CONCLUSION: Deficiency of KP in females with unexplained infertility was associated with reduced chances of implantation after ICSI.
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spelling pubmed-53474572017-07-01 Kisspeptin: A Potential Factor for Unexplained Infertility and Impaired Embryo Implantation Mumtaz, Aaida Khalid, Aqsa Jamil, Zehra Fatima, Syeda Sadia Arif, Sara Rehman, Rehana Int J Fertil Steril Original Article BACKGROUND: Kisspeptin (KP) is a neuropeptide that causes the release of the gonadotropin releasing hormone, which controls hypothalamo pituitary ovarian axis and exerts a number of peripheral effects on reproductive organs. The primary objective of this study was to compare baseline KP levels in females with different types of infertility and identify possible correlations with risk of failure to conceive, preclinical abortion and pregnancy after intracytoplasmic sperm injection (ICSI). MATERIALS AND METHODS: A longitudinal cohort study was carried out from August 2014 until May 2015 by recruiting 124 female patients undergoing ICSI, after obtaining ethical approval from the Australian Concept Infertility Medical Center. Cause of infertility due to male, female and unexplained factors was at a frequency of 32 (24%), 33 (31%) and 59 (45%) among the individuals respectively. KP levels were measured by ELISA assay before the initiation of the ICSI treatment protocol. Outcome of ICSI was categorized into three groups of non-pregnant with beta-human chorionic gonadotropin (β-hCG)<5-25 mIU/ml, preclinical abortion with β-hCG>25 mIU/ml and no cardiac activity, and clinical pregnancy declared upon confirmation of cardiac activity. Results based on cause of infertility and outcome groups were analyzed by one-way ANOVA. RESULTS: Females with unexplained infertility had significantly lower levels of KP when compared with those with male factor infertility (176.69 ± 5.03 vs. 397.6 ± 58.2, P=0.001). Clinical pregnancy was observed in 28 (23%) females of which 17 (71%) had a female cause of infertility. In the non-pregnant group of 66 (53%) females, common cause of infertility was unexplained 56(85%). A weak positive correlation of KP levels with fertilized oocytes and endometrial thickness was observed (P=0.04 and 0.01 respectively). CONCLUSION: Deficiency of KP in females with unexplained infertility was associated with reduced chances of implantation after ICSI. Royan Institute 2017 2017-02-16 /pmc/articles/PMC5347457/ /pubmed/28670427 http://dx.doi.org/10.22074/ijfs.2017.4957 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mumtaz, Aaida
Khalid, Aqsa
Jamil, Zehra
Fatima, Syeda Sadia
Arif, Sara
Rehman, Rehana
Kisspeptin: A Potential Factor for Unexplained Infertility and Impaired Embryo Implantation
title Kisspeptin: A Potential Factor for Unexplained Infertility and Impaired Embryo Implantation
title_full Kisspeptin: A Potential Factor for Unexplained Infertility and Impaired Embryo Implantation
title_fullStr Kisspeptin: A Potential Factor for Unexplained Infertility and Impaired Embryo Implantation
title_full_unstemmed Kisspeptin: A Potential Factor for Unexplained Infertility and Impaired Embryo Implantation
title_short Kisspeptin: A Potential Factor for Unexplained Infertility and Impaired Embryo Implantation
title_sort kisspeptin: a potential factor for unexplained infertility and impaired embryo implantation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347457/
https://www.ncbi.nlm.nih.gov/pubmed/28670427
http://dx.doi.org/10.22074/ijfs.2017.4957
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