Heterotypic paracrine signaling drives fibroblast senescence and tumor progression of large cell carcinoma of the lung

Senescence in cancer cells acts as a tumor suppressor, whereas in fibroblasts enhances tumor growth. Senescence has been reported in tumor associated fibroblasts (TAFs) from a growing list of cancer subtypes. However, the presence of senescent TAFs in lung cancer remains undefined. We examined senes...

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Detalles Bibliográficos
Autores principales: Lugo, Roberto, Gabasa, Marta, Andriani, Francesca, Puig, Marta, Facchinetti, Federica, Ramírez, Josep, Gómez-Caro, Abel, Pastorino, Ugo, Fuster, Gemma, Almendros, Isaac, Gascón, Pere, Davalos, Albert, Reguart, Noemí, Roz, Luca, Alcaraz, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347694/
https://www.ncbi.nlm.nih.gov/pubmed/27384989
http://dx.doi.org/10.18632/oncotarget.10327

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