Combinatorial effects of doxorubicin and retargeted tissue factor by intratumoral entrapment of doxorubicin and proapoptotic increase of tumor vascular infarction

Truncated tissue factor (tTF), retargeted to tumor vasculature by GNGRAHA peptide (tTF-NGR), and doxorubicin have therapeutic activity against a variety of tumors. We report on combination experiments of both drugs using different schedules. We have tested fluorescence- and HPLC-based intratumoral p...

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Detalles Bibliográficos
Autores principales: Stucke-Ring, Janine, Ronnacker, Julian, Brand, Caroline, Höltke, Carsten, Schliemann, Christoph, Kessler, Torsten, Schmidt, Lars Henning, Harrach, Saliha, Mantke, Verena, Hintelmann, Heike, Hartmann, Wolfgang, Wardelmann, Eva, Lenz, Georg, Wünsch, Bernhard, Müller-Tidow, Carsten, Mesters, Rolf M., Schwöppe, Christian, Berdel, Wolfgang E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347705/
https://www.ncbi.nlm.nih.gov/pubmed/27738341
http://dx.doi.org/10.18632/oncotarget.12559

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