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Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma

Radiotherapy (RT) is the normative therapeutic treatment for primary nasopharyngeal carcinoma (NPC). Single nucleotide polymorphisms (SNPs) of genes in Wnt/β-catenin pathway are correlated to the development, prognosis, and treatment benefit of various cancers. However, it has not been established w...

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Autores principales: Yu, Jingjing, Huang, Yuling, Liu, Lijuan, Wang, Jing, Yin, Jiye, Huang, Lihua, Chen, Shaojun, Li, Jingao, Yuan, Hong, Yang, Guoping, Liu, Wenyu, Wang, Hai, Pei, Qi, Guo, Chengxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347711/
https://www.ncbi.nlm.nih.gov/pubmed/27769064
http://dx.doi.org/10.18632/oncotarget.12754
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author Yu, Jingjing
Huang, Yuling
Liu, Lijuan
Wang, Jing
Yin, Jiye
Huang, Lihua
Chen, Shaojun
Li, Jingao
Yuan, Hong
Yang, Guoping
Liu, Wenyu
Wang, Hai
Pei, Qi
Guo, Chengxian
author_facet Yu, Jingjing
Huang, Yuling
Liu, Lijuan
Wang, Jing
Yin, Jiye
Huang, Lihua
Chen, Shaojun
Li, Jingao
Yuan, Hong
Yang, Guoping
Liu, Wenyu
Wang, Hai
Pei, Qi
Guo, Chengxian
author_sort Yu, Jingjing
collection PubMed
description Radiotherapy (RT) is the normative therapeutic treatment for primary nasopharyngeal carcinoma (NPC). Single nucleotide polymorphisms (SNPs) of genes in Wnt/β-catenin pathway are correlated to the development, prognosis, and treatment benefit of various cancers. However, it has not been established whether SNPs of Wnt/β-catenin pathway are associated with nasopharyngeal tumorigenesis and the efficacy of RT in NPC patients. Therefore, in this study, we aimed to investigate the nine potentially functional SNPs of four genes in the Wnt/β-catenin pathway and genotyped these in 188 NPC patients treated with RT. To achieve this goal, associations between these SNPs and the RT's curative efficacy, as well as acute radiation-induced toxic reaction were determined by multifactorial logistic regression. We observed that catenin beta 1 gene (CTNNB1) rs1880481 and rs3864004, and glycogen synthase kinase 3 beta gene (GSK3β) rs3755557 polymorphisms were significantly associated with poorer efficacy of RT in NPC patients. Moreover, GSK3β rs375557 and adenomatous polyposis coli gene (APC) rs454886 polymorphisms were correlated with acute grade 3–4 radiation-induced dermatitis and oral mucositis, respectively. In conclusion, this study suggests that gene polymorphisms of Wnt/β-catenin may be novel prognostic factors for NPC patients treated with RT.
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spelling pubmed-53477112017-03-31 Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma Yu, Jingjing Huang, Yuling Liu, Lijuan Wang, Jing Yin, Jiye Huang, Lihua Chen, Shaojun Li, Jingao Yuan, Hong Yang, Guoping Liu, Wenyu Wang, Hai Pei, Qi Guo, Chengxian Oncotarget Research Paper Radiotherapy (RT) is the normative therapeutic treatment for primary nasopharyngeal carcinoma (NPC). Single nucleotide polymorphisms (SNPs) of genes in Wnt/β-catenin pathway are correlated to the development, prognosis, and treatment benefit of various cancers. However, it has not been established whether SNPs of Wnt/β-catenin pathway are associated with nasopharyngeal tumorigenesis and the efficacy of RT in NPC patients. Therefore, in this study, we aimed to investigate the nine potentially functional SNPs of four genes in the Wnt/β-catenin pathway and genotyped these in 188 NPC patients treated with RT. To achieve this goal, associations between these SNPs and the RT's curative efficacy, as well as acute radiation-induced toxic reaction were determined by multifactorial logistic regression. We observed that catenin beta 1 gene (CTNNB1) rs1880481 and rs3864004, and glycogen synthase kinase 3 beta gene (GSK3β) rs3755557 polymorphisms were significantly associated with poorer efficacy of RT in NPC patients. Moreover, GSK3β rs375557 and adenomatous polyposis coli gene (APC) rs454886 polymorphisms were correlated with acute grade 3–4 radiation-induced dermatitis and oral mucositis, respectively. In conclusion, this study suggests that gene polymorphisms of Wnt/β-catenin may be novel prognostic factors for NPC patients treated with RT. Impact Journals LLC 2016-10-19 /pmc/articles/PMC5347711/ /pubmed/27769064 http://dx.doi.org/10.18632/oncotarget.12754 Text en Copyright: © 2016 Yu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Yu, Jingjing
Huang, Yuling
Liu, Lijuan
Wang, Jing
Yin, Jiye
Huang, Lihua
Chen, Shaojun
Li, Jingao
Yuan, Hong
Yang, Guoping
Liu, Wenyu
Wang, Hai
Pei, Qi
Guo, Chengxian
Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma
title Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma
title_full Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma
title_fullStr Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma
title_full_unstemmed Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma
title_short Genetic polymorphisms of Wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma
title_sort genetic polymorphisms of wnt/β-catenin pathway genes are associated with the efficacy and toxicities of radiotherapy in patients with nasopharyngeal carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347711/
https://www.ncbi.nlm.nih.gov/pubmed/27769064
http://dx.doi.org/10.18632/oncotarget.12754
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