Novel MDM2 inhibitor SAR405838 (MI-773) induces p53-mediated apoptosis in neuroblastoma

Neuroblastoma (NB), which accounts for about 15% of cancer-related mortality in children, is the most common childhood extracranial malignant tumor. In NB, somatic mutations of the tumor suppressor, p53, are exceedingly rare. Unlike in adult tumors, the majority of p53 downstream functions are still...

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Detalles Bibliográficos
Autores principales: Lu, Jiaxiong, Guan, Shan, Zhao, Yanling, Yu, Yang, Wang, Yongfeng, Shi, Yonghua, Mao, Xinfang, Yang, Kristine L., Sun, Wenjing, Xu, Xin, Yi, Joanna S., Yang, Tianshu, Yang, Jianhua, Nuchtern, Jed G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347730/
https://www.ncbi.nlm.nih.gov/pubmed/27764791
http://dx.doi.org/10.18632/oncotarget.12634

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