TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis

Accumulating evidences suggested that tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene rs10499194, rs13207033 polymorphisms may be associated with the risk of rheumatoid arthritis (RA). However, these studies yielded contradictory findings. To clarify convincing associations, we conduc...

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Autores principales: Wang, Ming-Jie, Yang, Hao-Yu, Zhang, Hui, Zhou, Xindie, Liu, Rui-Ping, Mi, Yuan-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347742/
https://www.ncbi.nlm.nih.gov/pubmed/27779104
http://dx.doi.org/10.18632/oncotarget.12638
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author Wang, Ming-Jie
Yang, Hao-Yu
Zhang, Hui
Zhou, Xindie
Liu, Rui-Ping
Mi, Yuan-Yuan
author_facet Wang, Ming-Jie
Yang, Hao-Yu
Zhang, Hui
Zhou, Xindie
Liu, Rui-Ping
Mi, Yuan-Yuan
author_sort Wang, Ming-Jie
collection PubMed
description Accumulating evidences suggested that tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene rs10499194, rs13207033 polymorphisms may be associated with the risk of rheumatoid arthritis (RA). However, these studies yielded contradictory findings. To clarify convincing associations, we conducted a comprehensive meta-analysis by searching in PubMed, Embase, and the China Knowledge Resource Integrated Database. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. A total of 13 case-control studies for rs10499194 polymorphism and 6 studies for rs13207033 polymorphism were included. Our data indicated that TNFAIP3 gene rs10499194, rs13207033 polymorphisms were associated with the decreased risk of RA. Stratification analyses of ethnicity indicated rs10499194, rs13207033 polymorphisms decreased the risk of RA among Caucasian populations, but not among Asian populations. In conclusion, this meta-analysis indicates that TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of RA, especially among Caucasian populations.
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spelling pubmed-53477422017-03-31 TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis Wang, Ming-Jie Yang, Hao-Yu Zhang, Hui Zhou, Xindie Liu, Rui-Ping Mi, Yuan-Yuan Oncotarget Research Paper Accumulating evidences suggested that tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene rs10499194, rs13207033 polymorphisms may be associated with the risk of rheumatoid arthritis (RA). However, these studies yielded contradictory findings. To clarify convincing associations, we conducted a comprehensive meta-analysis by searching in PubMed, Embase, and the China Knowledge Resource Integrated Database. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. A total of 13 case-control studies for rs10499194 polymorphism and 6 studies for rs13207033 polymorphism were included. Our data indicated that TNFAIP3 gene rs10499194, rs13207033 polymorphisms were associated with the decreased risk of RA. Stratification analyses of ethnicity indicated rs10499194, rs13207033 polymorphisms decreased the risk of RA among Caucasian populations, but not among Asian populations. In conclusion, this meta-analysis indicates that TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of RA, especially among Caucasian populations. Impact Journals LLC 2016-10-13 /pmc/articles/PMC5347742/ /pubmed/27779104 http://dx.doi.org/10.18632/oncotarget.12638 Text en Copyright: © 2016 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wang, Ming-Jie
Yang, Hao-Yu
Zhang, Hui
Zhou, Xindie
Liu, Rui-Ping
Mi, Yuan-Yuan
TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis
title TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis
title_full TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis
title_fullStr TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis
title_full_unstemmed TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis
title_short TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis
title_sort tnfaip3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347742/
https://www.ncbi.nlm.nih.gov/pubmed/27779104
http://dx.doi.org/10.18632/oncotarget.12638
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