PRIMA-1(Met) suppresses colorectal cancer independent of p53 by targeting MEK

PRIMA-1(Met) is the methylated PRIMA-1 (p53 reactivation and induction of massive apoptosis) and could restore tumor suppressor function of mutant p53 and induce p53 dependent apoptosis in cancer cells harboring mutant p53. However, p53 independent activity of PRIMA-1(Met) remains elusive. Here we r...

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Detalles Bibliográficos
Autores principales: Lu, Tao, Zou, Yanmei, Xu, Guogang, Potter, Jane A., Taylor, Garry L., Duan, Qiuhong, Yang, Qin, Xiong, Huihua, Qiu, Hong, Ye, Dawei, Zhang, Peng, Yu, Shiying, Yuan, Xianglin, Zhu, Feng, Wang, Yihua, Xiong, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347749/
https://www.ncbi.nlm.nih.gov/pubmed/27806324
http://dx.doi.org/10.18632/oncotarget.12940

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