PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway

PICT-1 is an essential ribosome biogenesis factor whose loss induces p53 accumulation and apoptosis. Here, we show that DNA damage changes PICT-1 localization and decreases PICT-1 protein levels via the proteasome pathway. Two important phosphatidylinositol 3-kinase-like kinases (PIKKs), ataxia-tela...

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Detalles Bibliográficos
Autores principales: Chen, Hongbo, Han, Liqiao, Tsai, Hsiangi, Wang, Zhiwei, Wu, Yanping, Duo, Yanhong, Cao, Wei, Chen, Lijun, Tan, Zhirong, Xu, Ning, Huang, Xianzhang, Zhuang, Junhua, Huang, Laiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347766/
https://www.ncbi.nlm.nih.gov/pubmed/27829214
http://dx.doi.org/10.18632/oncotarget.13082

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