CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells

Triplebodies are antibody-derived recombinant proteins carrying 3 antigen-binding domains in a single polypeptide chain. Triplebody SPM-1 was designed for lysis of CD19-bearing malignant B-lymphoid cells through the engagement of CD16-expressing cytolytic effectors, including NK and γδ T cells. SPM-...

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Detalles Bibliográficos
Autores principales: Schiller, Christian B., Braciak, Todd A., Fenn, Nadja C., Seidel, Ursula J. E., Roskopf, Claudia C., Wildenhain, Sarah, Honegger, Annemarie, Schubert, Ingo A., Schele, Alexandra, Lämmermann, Kerstin, Fey, Georg H., Jacob, Uwe, Lang, Peter, Hopfner, Karl-Peter, Oduncu, Fuat S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347777/
https://www.ncbi.nlm.nih.gov/pubmed/27825135
http://dx.doi.org/10.18632/oncotarget.13110

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