Cargando…

Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells

BACKGROUND: Multiple iterations of chimeric antigen receptors (CARs) have been developed, mainly focusing on intracellular signaling modules. However, the effect of non-signaling extracellular modules on the expansion and therapeutic efficacy of CARs remains largely undefined. METHODS: We generated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qin, Le, Lai, Yunxin, Zhao, Ruocong, Wei, Xinru, Weng, Jianyu, Lai, Peilong, Li, Baiheng, Lin, Simiao, Wang, Suna, Wu, Qiting, Liang, Qiubin, Li, Yangqiu, Zhang, Xuchao, Wu, Yilong, Liu, Pentao, Yao, Yao, Pei, Duanqing, Du, Xin, Li, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347831/ https://www.ncbi.nlm.nih.gov/pubmed/28288656 http://dx.doi.org/10.1186/s13045-017-0437-8

Ejemplares similares

DNAX-activating protein 10 co-stimulation enhances the anti-tumor efficacy of chimeric antigen receptor T cells
por: Zhao, Ruocong, et al.
Publicado: (2018)

CRISPR/Cas9-Mediated Deletion of Foxn1 in NOD/SCID/IL2rg(−/−) Mice Results in Severe Immunodeficiency
por: Wei, Xinru, et al.
Publicado: (2017)

Anti-GPC3-CAR T Cells Suppress the Growth of Tumor Cells in Patient-Derived Xenografts of Hepatocellular Carcinoma
por: Jiang, Zhiwu, et al.
Publicado: (2017)

CD215+ Myeloid Cells Respond to Interleukin 15 Stimulation and Promote Tumor Progression
por: Lin, Shouheng, et al.
Publicado: (2017)

Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia
por: Jiang, Zhiwu, et al.
Publicado: (2017)

Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer
por: Lv, Jiang, et al.
Publicado: (2019)

Chimeric antigen receptor T cells targeting PD-L1 suppress tumor growth
por: Qin, Le, et al.
Publicado: (2020)

Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized
por: Jiang, Zhiwu, et al.
Publicado: (2016)

PSCA is a target of chimeric antigen receptor T cells in gastric cancer
por: Wu, Di, et al.
Publicado: (2020)

The Chemokine Receptor CCR8 Is a Target of Chimeric Antigen T Cells for Treating T Cell Malignancies
por: Zheng, Diwei, et al.
Publicado: (2022)

GZD824 suppresses the growth of human B cell precursor acute lymphoblastic leukemia cells by inhibiting the SRC kinase and PI3K/AKT pathways
por: Ye, Wei, et al.
Publicado: (2016)

Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments
por: Ye, Wei, et al.
Publicado: (2015)

Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis
por: Qin, Le, et al.
Publicado: (2022)

Overexpression of the long non-coding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia
por: Zeng, Chengwu, et al.
Publicado: (2015)

Chimeric CTLA4-CD28-CD3z T Cells Potentiate Antitumor Activity Against CD80/CD86–Positive B Cell Malignancies
por: Lin, Shouheng, et al.
Publicado: (2021)

Alternative expression of TCRζ related genes in patients with chronic myeloid leukemia
por: Zha, Xianfeng, et al.
Publicado: (2012)

DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D
por: Li, Shanglin, et al.
Publicado: (2022)

Oligoclonal expansion of TCR Vδ T cells may be a potential immune biomarker for clinical outcome of acute myeloid leukemia
por: Jin, Zhenyi, et al.
Publicado: (2016)

Human Hyaluronidase PH20 Potentiates the Antitumor Activities of Mesothelin-Specific CAR-T Cells Against Gastric Cancer
por: Zhao, Ruocong, et al.
Publicado: (2021)

Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells
por: Xiao, Yiren, et al.
Publicado: (2015)

Transcriptomic analysis identifies the S100 calcium-binding protein β subunit (S100B) and intercellular adhesion molecule-1 (ICAM-1) as potential diagnostic biomarkers for acute cerebral infarction
por: Cheng, Dan, et al.
Publicado: (2023)

Altered expression of the TCR signaling related genes CD3 and FcεRIγ in patients with aplastic anemia
por: Li, Bo, et al.
Publicado: (2012)

Next-generation sequencing of circulating tumor DNA for detection of gene mutations in lung cancer: implications for precision treatment
por: Lai, Jinhuo, et al.
Publicado: (2018)

In situ antigen modification-based target-redirected universal chimeric antigen receptor T (TRUE CAR-T) cell therapy in solid tumors
por: Sun, Zhichen, et al.
Publicado: (2022)

Single-cell analysis reveals the lncRNA-MEG3/miRNA-133a-3p/PRRT2 axis regulates skeletal muscle regeneration and myogenesis
por: Yao, Yilong, et al.
Publicado: (2022)

Challenges and advances in clinical applications of mesenchymal stromal cells
por: Zhou, Tian, et al.
Publicado: (2021)

A focused transcriptomic analysis of the TP53-regulated genes identifies the GPI-anchored molecule-like protein (GML) as a favorable prognostic predictor of lung cancer
por: Wang, Yutong, et al.
Publicado: (2022)

Disruption of CISH promotes the antitumor activity of human T cells and decreases PD-1 expression levels
por: Lv, Jiang, et al.
Publicado: (2022)

Anti-C4d chimeric antigen receptor regulatory T cells suppressed allograft rejection in ABO-incompatible heart transplantation
por: Lee, Sun-Kyung, et al.
Publicado: (2021)

Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold
por: Fujiwara, Kento, et al.
Publicado: (2020)

C3aR costimulation enhances the antitumor efficacy of CAR-T cell therapy through Th17 expansion and memory T cell induction
por: Lai, Peilong, et al.
Publicado: (2022)

Hepatocyte-specific deletion of Mettl3 promotes hepatocellular carcinoma in mice
por: Liu, Chunhong, et al.
Publicado: (2023)

The Effects of Chimeric Antigen Receptor (CAR) Hinge Domain Post-Translational Modifications on CAR-T Cell Activity
por: Hirobe, Sachiko, et al.
Publicado: (2022)

Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes
por: Li, Wei, et al.
Publicado: (2015)

Human induced-T-to-natural killer cells have potent anti-tumour activities
por: Jiang, Zhiwu, et al.
Publicado: (2022)

Distinct clinical profiles and mutation landscapes of gliomas originating from the neocortex, mesocortex, and cerebellum
por: Cheng, Ye, et al.
Publicado: (2023)

The complete chloroplast genome of Epilobium hirsutum L. (Onagraceae)
por: Meng, Fei, et al.
Publicado: (2021)

A novel mutation of glycogen synthase kinase-3β leads to a reduced level of GSK3β protein in a patient with dilated cardiomyopathy
por: Gong, Ke, et al.
Publicado: (2023)

Single-Cell RNA Sequencing Reveals Transcriptional Changes in the Cartilage of Subchondral Insufficiency Fracture of the Knee
por: Tang, Wang, et al.
Publicado: (2022)

Therapeutic genome editing of an aberrant splice site in β-thalassemia by CRISPR/Cas9 with multiple sgRNAs
por: Yang, Fei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_66p6cphnp3n12sqbdtpm85mq03