Cargando…

A Hexasaccharide Containing Rare 2‐O‐Sulfate‐Glucuronic Acid Residues Selectively Activates Heparin Cofactor II

Glycosaminoglycan (GAG) sequences that selectively target heparin cofactor II (HCII), a key serpin present in human plasma, remain unknown. Using a computational strategy on a library of 46 656 heparan sulfate hexasaccharides we identified a rare sequence consisting of consecutive glucuronic acid 2‐...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sankarayanarayanan, Nehru Viji, Strebel, Tamara R., Boothello, Rio S., Sheerin, Kevin, Raghuraman, Arjun, Sallas, Florence, Mosier, Philip D., Watermeyer, Nicholas D., Oscarson, Stefan, Desai, Umesh R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347859/ https://www.ncbi.nlm.nih.gov/pubmed/28124818 http://dx.doi.org/10.1002/anie.201609541

Ejemplares similares

Understanding Dermatan Sulfate−Heparin Cofactor II Interaction through Virtual Library Screening
por: Raghuraman, Arjun, et al.
Publicado: (2010)

Heparan sulfate hexasaccharide selectively inhibits cancer stem cells self-renewal by activating p38 MAP kinase
por: Patel, Nirmita J., et al.
Publicado: (2016)

Interactions of Pleiotrophin with a Structurally Defined Heparin Hexasaccharide
por: Ryan, Eathen O., et al.
Publicado: (2021)

Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2–Chondroitin Sulfate System
por: Sankaranarayanan, Nehru Viji, et al.
Publicado: (2021)

In-Depth Molecular Dynamics Study of All Possible Chondroitin Sulfate Disaccharides Reveals Key Insight into Structural Heterogeneity and Dynamism
por: Nagarajan, Balaji, et al.
Publicado: (2022)

Combinatorial virtual library screening analysis of antithrombin binding oligosaccharide motif generation by heparan sulfate 3-O-Sulfotransferase 1()
por: Sankaranarayanan, Nehru Viji, et al.
Publicado: (2020)

A molecular dynamics-based algorithm for evaluating the glycosaminoglycan mimicking potential of synthetic, homogenous, sulfated small molecules
por: Nagarajan, Balaji, et al.
Publicado: (2017)

On the Specificity of Heparin/Heparan Sulfate Binding to Proteins. Anion-Binding Sites on Antithrombin and Thrombin Are Fundamentally Different
por: Mosier, Philip D., et al.
Publicado: (2012)

On the Selectivity of Heparan Sulfate Recognition by SARS-CoV-2 Spike Glycoprotein
por: Chittum, John E., et al.
Publicado: (2021)

Preferential recognition and antagonism of SARS-CoV-2 spike glycoprotein binding to 3-O-sulfated heparan sulfate
por: Tiwari, Vaibhav, et al.
Publicado: (2020)

Designing Smaller, Synthetic, Functional Mimetics of Sulfated Glycosaminoglycans as Allosteric Modulators of Coagulation Factors
por: Abdelfadiel, Elsamani I., et al.
Publicado: (2023)

Identification of keratan sulfate disaccharide at C-3 position of glucuronate of chondroitin sulfate from Mactra chinensis
por: Higashi, Kyohei, et al.
Publicado: (2016)

Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin
por: Townsend, David, et al.
Publicado: (2020)

Recombinant dermatan sulfate is a potent activator of heparin cofactor II-dependent inhibition of thrombin
por: Tykesson, Emil, et al.
Publicado: (2019)

High dose acetaminophen inhibits STAT3 and has free radical independent anti-cancer stem cell activity
por: Pingali, Pavani, et al.
Publicado: (2021)

Synthesis of a Glucuronic Acid‐Containing Thioglycoside Trisaccharide Building Block and Its Use in the Assembly of Cryptococcus Neoformans Capsular Polysaccharide Fragments
por: Guazzelli, Lorenzo, et al.
Publicado: (2015)

Synthesis of a hexasaccharide partial sequence of hyaluronan for click chemistry and more
por: Bantzi, Marina, et al.
Publicado: (2015)

d-Glucuronate and d-Glucuronate Glycal Acceptors for the Scalable Synthesis of d-GlcN-α-1,4-d-GlcA Disaccharides and Modular Assembly of Heparan Sulfate
por: Pongener, Imlirenla, et al.
Publicado: (2023)

Adsorption and Elution of Glucuronic Acid and Chondroitin Sulfate Using Amino-Group-Containing Spherical Gel
por: Nakashima, Izumi, et al.
Publicado: (2016)

Protection against Experimental Melioidosis with a Synthetic manno-Heptopyranose Hexasaccharide Glycoconjugate
por: Scott, Andrew E., et al.
Publicado: (2016)

Solution structure of CXCL13 and heparan sulfate binding show that GAG binding site and cellular signalling rely on distinct domains
por: Monneau, Yoan R., et al.
Publicado: (2017)

Total synthesis of periploside A, a unique pregnane hexasaccharide with potent immunosuppressive effects
por: Zhang, Xiaheng, et al.
Publicado: (2015)

Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity
por: Morla, Shravan, et al.
Publicado: (2023)

Glycan Modulation of Insulin‐like Growth Factor‐1 Receptor
por: Boothello, Rio S., et al.
Publicado: (2022)

Synthesis of a Fluorous-Tagged Hexasaccharide and Interaction with Growth Factors Using Sugar-Coated Microplates
por: Maza, Susana, et al.
Publicado: (2019)

Total synthesis of a Streptococcus pneumoniae serotype 12F CPS repeating unit hexasaccharide
por: Seeberger, Peter H, et al.
Publicado: (2017)

Discovering small-molecule therapeutics against SARS-CoV-2
por: Tiwari, Vaibhav, et al.
Publicado: (2020)

The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms
por: Hasan, Mahmudul, et al.
Publicado: (2020)

Biosensor development for single-cell detection of glucuronate
por: Nash, Jennifer Kaczmarek, et al.
Publicado: (2023)

Dermatan sulfate in tunicate phylogeny: Order-specific sulfation pattern and the effect of [→4IdoA(2-Sulfate)β-1→3GalNAc(4-Sulfate)β-1→] motifs in dermatan sulfate on heparin cofactor II activity
por: Kozlowski, Eliene O, et al.
Publicado: (2011)

A Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding Proteins
por: Sarkar, Aurijit, et al.
Publicado: (2015)

Correction: Dermatan sulfate in tunicate phylogeny: Order-specific sulfation pattern and the effect of [→4IdoA(2-Sulfate)β-1→3GalNAc(4-Sulfate)β-1→] motifs in dermatan sulfate on heparin cofactor II activity
por: Kozlowski, Eliene O, et al.
Publicado: (2011)

RNAi targeting heparin cofactor II promotes hemostasis in hemophilia A
por: Lin, Wen-yi, et al.
Publicado: (2021)

Synthesis of Glycosides of Glucuronic, Galacturonic and Mannuronic Acids: An Overview
por: Wadouachi, Anne, et al.
Publicado: (2011)

Mechanistic characterization of UDP‐glucuronic acid 4‐epimerase
por: Borg, Annika J. E., et al.
Publicado: (2020)

Tunicate Heparan Sulfate Enriched in 2-Sulfated β-Glucuronic Acid: Structure, Anticoagulant Activity, and Inhibitory Effect on the Binding of Human Colon Adenocarcinoma Cells to Immobilized P-Selectin
por: Abreu, Wallace S., et al.
Publicado: (2019)

Heparin Cofactor II: A Novel Plausible Link of Obesity and Diabetes with Thrombosis
por: Hasegawa, Yutaka, et al.
Publicado: (2017)

Carboxylated Glucuronic Poly-amido-saccharides as Protein Stabilizing Agents
por: Stidham, Sarah E., et al.
Publicado: (2014)

UDP-Glucuronic Acid Transport Is Required for Virulence of Cryptococcus neoformans
por: Li, Lucy X., et al.
Publicado: (2018)

Circulating glucuronic acid predicts healthspan and longevity in humans and mice
por: Ho, Andrew, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_r95h88cp2m0mkvreajqr9i4488