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Rapid Activation of Transforming Growth Factor β–Activated Kinase 1 in Chondrocytes by Phosphorylation and K(63)‐Linked Polyubiquitination Upon Injury to Animal Articular Cartilage

OBJECTIVE: Mechanical injury to cartilage predisposes to osteoarthritis (OA). Wounding of the articular cartilage surface causes rapid activation of MAP kinases and NF‐κB, mimicking the response to inflammatory cytokines. This study was undertaken to identify the upstream signaling mechanisms involv...

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Detalles Bibliográficos
Autores principales:	Ismail, Heba M., Didangelos, Athanasios, Vincent, Tonia L., Saklatvala, Jeremy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Osteoarthritis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347887/ https://www.ncbi.nlm.nih.gov/pubmed/27768832 http://dx.doi.org/10.1002/art.39965

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