Increased risk of essential tremor in migraine: A population-based retrospective cohort study

PURPOSE: To examine the long-term risk of essential tremor (ET) in migraine. METHODS: Using population-based administrative data from a subset of the National Health Insurance Research Database (NHIRD) of Taiwan, we identified 22,696 newly diagnosed migraineurs (mean age 44.5 years) and a matched mi...

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Detalles Bibliográficos
Autores principales: Lau, Chi-Ieong, Lin, Che-Chen, Chen, Hsuan-Ju, Wang, Han-Cheng, Chen, Wei-Hung, Liang, Ji-An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348003/
https://www.ncbi.nlm.nih.gov/pubmed/28288163
http://dx.doi.org/10.1371/journal.pone.0173586
Descripción
Sumario:PURPOSE: To examine the long-term risk of essential tremor (ET) in migraine. METHODS: Using population-based administrative data from a subset of the National Health Insurance Research Database (NHIRD) of Taiwan, we identified 22,696 newly diagnosed migraineurs (mean age 44.5 years) and a matched migraine-free cohort of 90,784 individuals in the period 2000–2008. Multivariable Cox proportional hazards regression analysis was conducted for assessing the ET risk for the migraine cohort compared to the migraine-free cohort. RESULTS: After adjusting for covariates, the migraine cohort had a 1.83-fold increased risk (95% CI 1.50–2.23) of subsequent ET in comparison to the migraine-free cohort (8.97 vs. 4.81 per 10,000 person-years). In the subgroup analysis, patients with migraine were associated with higher risks of ET, regardless of gender, age or the existence of comorbidities. CONCLUSION: Our findings demonstrated an association between migraine and ET, suggesting a possible shared pathophysiology underpinning both disorders.

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